Abstract
Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.
Method: Among these compounds, 7b, 7d, 7e, and 7f exhibited potent anticancer activity against the cell lines tested. The cytotoxicity of the synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, and daunorubicin). Result: Thus, synthesized 1,4-dihydropyridines can be considered as the encouraging molecules for further drug development as anticancer agents.Keywords: Anticancer activity, antipoliferative activity, benzylpyridinium salt, 1, 4-dihydropyridine, MTT assay.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent
Volume: 17 Issue: 7
Author(s): Denish Viradiya, Sheefa Mirza, Faraz Shaikh, Rajesh Kakadiya*, Anand Rathod, Nayan Jain, Rakesh Rawal*Anamik Shah*
Affiliation:
- Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot,India
- Gujarat Cancer Research Institute, Asarwa, Ahmedabad, Gujarat,India
- Center of Excellence, National Facility for Drug Discovery Center, Department of Chemistry, Saurashtra University, Rajkot,India
Keywords: Anticancer activity, antipoliferative activity, benzylpyridinium salt, 1, 4-dihydropyridine, MTT assay.
Abstract: Aims: A series of 1,4-dihydropyridine based compounds bearing benzylpyridinium moiety have been designed and evaluated for in vitro anticancer activity against glioblastoma U87MG, lung cancer A549 and colorectal adenocarcinoma Caco-2 cell lines using the MTT assay.
Method: Among these compounds, 7b, 7d, 7e, and 7f exhibited potent anticancer activity against the cell lines tested. The cytotoxicity of the synthesized derivatives was compared to standard drugs (carboplatin, gemcitabine, and daunorubicin). Result: Thus, synthesized 1,4-dihydropyridines can be considered as the encouraging molecules for further drug development as anticancer agents.Export Options
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Cite this article as:
Viradiya Denish, Mirza Sheefa, Shaikh Faraz, Kakadiya Rajesh*, Rathod Anand, Jain Nayan, Rawal Rakesh*, Shah Anamik*, Design and Synthesis of 1,4-dihydropyridine Derivatives as Anti-cancer Agent, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (7) . https://dx.doi.org/10.2174/1871520616666161206143251
DOI https://dx.doi.org/10.2174/1871520616666161206143251 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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