Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione

Title:Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione

Volume: 17 Issue: 8

Author(s): Abbas Ahmadi*, Mohsen Khalili, Lida Sohrabi, Nazanin Delzendeh, Babak Nahri-Niknafs and Fariba Ansari

Affiliation:

• Department of Medicinal Chemistry, Pharmaceutical Sciences Branch, Islamic Azad University, No 99, Yakhchal, Gholhak, Shariati, Tehran,Iran

Keywords: Hypoglycemic and hypolipidemic activities, STZ-induced diabetic rat model, Sulfonamide-benzothiazole Derivatives, Thiazolidinediones (TZDs).

Abstract: Background: Thiazolidinediones (TZDs) and sulfonamides are important and highly consumption class of antidiabetic drugs having insulin sensitizing and stimulating properties in patients with type 2 diabetes, respectively.

Objective: In this paper, some novel benzothiazole derivatives of TZD-sulfonamides were synthesized (I-IV) and evaluated for anti-hyperglycemic and anti-hyperlipidemic activities in the STZ-induced diabetic rat model.

Results: Results indicated that all new conjugated compounds showed significant hypoglycemic activities compared to control animals that were better for I and IV than others. Moreover, these new compounds displayed high efficiency for lowering lipid profiles as compared to control and standard (Pioglitazone) groups that was significant and higher for I than others.

Conclusion: It is concluded that these new conjugated TZD-sulfonamide-benzothiazoles (I-IV) can indicate useful results for hypoglycemic and hypolipidemic activities compared to control and standard groups, respectively with different mechanism that is closer to TZDs' analogs.

Cite this article as:

Ahmadi Abbas*, Khalili Mohsen, Sohrabi Lida, Delzendeh Nazanin, Nahri-Niknafs Babak and Ansari Fariba, Synthesis and Evaluation of the Hypoglycemic and Hypolipidemic Activity of Sulfonamide-benzothiazole Derivatives of Benzylidene-2,4- thiazolidnedione, Mini-Reviews in Medicinal Chemistry 2017; 17 (8) . https://dx.doi.org/10.2174/1389557516666161130095407

DOI https://dx.doi.org/10.2174/1389557516666161130095407	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607