独特的脯氨酰异构酶Pin1在癌症相关的病毒和细菌感染中的作用

Title:The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections

Volume: 16 Issue: 9

Author(s): J. Wang, X.-H. Liao, M. Zheng, D. Yang, X. Z. Zhou, H. Liu, K. P. Lu

Affiliation:

关键词: 脯氨酸异构酶Pin1，癌症相关的病毒和细菌感染、ATRA、炎症反应、NF-κBκ，Toll样受体

摘要: Infection is the process of pathogen invasion, as well as the host reaction to the foreign agents. Proline-directed phosphorylation is a major regulatory mechanism that regulates the function of fundamental proteins involved in infection and infection-induced cancer. Recently, the identification of the phosphorylation-dependent prolyl isomerase Pin1 has uncovered a unique regulatory signaling mechanism controlling protein conformation and function after phosphorylation. Pin1 is the only proline isomerase that specifically recognizes certain Pro-directed Ser/Thr phosphorylation motifs. Pin1 has emerged as a major regulator of cancerrelated viral and bacterial infections notably via activating Toll-like receptor signaling and NF-κB pathways. This paper will specifically review recent findings on the role of Pin1 in cancer-related viral and bacterial infections and also discuss newly discovered Pin1 inhibitors as promising drugs for the prevention and treatment of viral and bacterial infections and associated tumorigenesis.

Cite this article as:

J. Wang, X.-H. Liao, M. Zheng, D. Yang, X. Z. Zhou, H. Liu, K. P. Lu , The Roles of the Unique Prolyl Isomerase Pin1 in Cancer-Related Viral and Bacterial Infections, Current Molecular Medicine 2016; 16 (9) . https://dx.doi.org/10.2174/1566524016666161124103654