摘要
维生素D是一种重要的激素,能够调节许多与人类健康相关的病理学过程。尽管它的核受(VDR), 维生素D通过基因和表观遗传机制控制基因的表达。不断出现的数据显示维生素D在包括结肠癌在内的不同癌症中具有抗癌活性。本文对近期在理解维生素D的分子机制和其在结肠癌中上皮机制相互作用的研究进展进行了综述。维生素D改变了DNA甲基化和组蛋白甲基化的状态,产生结肠抑制和表达出肿瘤抑制剂的活性。此外,维生素D通过抑制miRNAs激活了肿瘤表达的活性,有助于抑制肿瘤活性。对维生素D上皮作用通过不诱导高钙血症的副作用来靶向维生素D信号通路的进一步的理解将有助于治疗性策略发展。
关键词: 维生素D,表观遗传学,微型RNA,DNA甲基化,组蛋白甲基化,化疗
Current Medicinal Chemistry
Title:Vitamin D and the Epigenetic Machinery in Colon Cancer
Volume: 24 Issue: 9
关键词: 维生素D,表观遗传学,微型RNA,DNA甲基化,组蛋白甲基化,化疗
摘要: Vitamin D is an important hormone that regulates many physiological processes related to human health. Through its nuclear receptor, VDR, vitamin D controls gene expression through genetic and epigenetic mechanisms. Increasing data have demonstrated the anti-cancer activities of vitamin D in various cancers, including colon cancer. This review summarizes the recent progresses in our understanding of the molecular mechanisms of vitamin D and its interaction with the epigenetic machinery in colon cancer. Vitamin D changes the status of DNA methylation and histone modifications, resulting in the activation of tumor suppressors and inhibition of oncogenes. In addition, vitamin D activates the expression of tumor suppressing miRNAs, which contribute to the tumor suppressive activity. Further understanding of the epigenetic action of vitamin D will help the development of therapeutic strategies targeting the vitamin D signaling pathway without inducing the hypercalcemic side effects.
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Cite this article as:
Vitamin D and the Epigenetic Machinery in Colon Cancer, Current Medicinal Chemistry 2017; 24 (9) . https://dx.doi.org/10.2174/0929867324666161117155325
DOI https://dx.doi.org/10.2174/0929867324666161117155325 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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