摘要
背景:两个大型全基因组相关试验已经证实MS4A基因簇的rs610932和rs670139多态性与欧洲血统的阿尔茨海默症(AD)易感人群有莫大关系。大量的研究专注于发现白种人和东亚人群MS4A基因变型和AD之间的联系。然而,因为每一次试验样本小,以至于每次的结果都不一致。 目的:我们进行了一项元分析来探索rs610932和rs670139多态性是否与AD易感性有联系。 方法:通过查找PubMed,MEDLINE和AlzGene数据库,这个元分析中包含了关于rs610932的19项研究(34119个案例和56956个对照)和关于rs670139的18项 研究(33622个案例和55322个对照)。 结果:通过使用额外的模型,我们的结果表现出在集中人群中rs610932和rs670139多态性与AD之间有密切联系。在亚群分析中,额外的和主要的模型显示出亚洲人群的rs610932有强烈相关(比值比=0.82,95%置信区间0.69-0.99,p=0.03和比值比=0.82,95%置信区间0.72-0.95,p=0.006),但隐形模型无显示。然而,三种模型都没有发现亚洲人群中rs670139与AD有联系。 结论:结果证明rs610932多态性导致了白种人与(东)亚洲人群AD易感性。就我们所知,这是研究亚洲和欧洲人群MS4A基因多态性与AD联系最大元分析。
关键词: 阿尔茨海默症,元分析,MS4A基因簇,rs610932,rs670139
Current Alzheimer Research
Title:Association of rs610932 and rs670139 Polymorphisms in the MS4A Gene Cluster with Alzheimer’s Disease: An Updated Meta-analysis
Volume: 14 Issue: 3
Author(s): Ruixia Zhu, Xu Liu, Zhiyi He.
Affiliation:
关键词: 阿尔茨海默症,元分析,MS4A基因簇,rs610932,rs670139
摘要: Background: Two large-scale genome-wide association studies have identified rs610932 and rs670139 polymorphisms within the MS4A gene cluster as being significantly associated with susceptibility to Alzheimer’s disease (AD) in those with European ancestry. A number of studies have focused on the association between MS4A gene variants and AD in Caucasian and East Asian populations. However, the results remain inconsistent owing to the small sample size in each study.
Objective: We performed a meta-analysis to explore whether rs610932 and rs670139 polymorphisms are associated with susceptibility to AD. Method: 19 studies with 34,119 cases and 56,956 controls concerning rs610932 and 18 studies with 33,622 cases and 55,322 controls concerning rs670139 were included in this meta-analysis by searching the PubMed, MEDLINE, and AlzGene databases. Results: Our results showed significant associations between rs610932 and rs670139 polymorphisms and AD in the pooled population using an additive model. In subgroup analysis, we also identified a significant association of rs610932 in the Asian population under additive [odds ratio=0.82, 95% confidence interval 0.69-0.99, p=0.03] and dominant models (odds ratio=0.82, 95% confidence interval 0.72-0.95, p=0.006), but not under a recessive model. However, no association was found between rs670139 and AD patients using all three of these models in the Asian population. Conclusion: Our results suggest that the rs610932 polymorphism contributes to AD susceptibility in Caucasian and Asian populations. To our knowledge, this is the largest meta-analysis to investigate the association between MS4A gene polymorphisms and AD in Asian and European populations.Export Options
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Cite this article as:
Ruixia Zhu, Xu Liu, Zhiyi He. , Association of rs610932 and rs670139 Polymorphisms in the MS4A Gene Cluster with Alzheimer’s Disease: An Updated Meta-analysis, Current Alzheimer Research 2017; 14 (3) . https://dx.doi.org/10.2174/1567205013666161108110828
DOI https://dx.doi.org/10.2174/1567205013666161108110828 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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