摘要
ylindrospermopsin(CYN)是一种由多种蓝细菌类生物产生的三环胍基生物碱毒素。它能改变包括动植物在内的真核生物的细胞功能。在过去的几十年里,越来越多的证据表明它对动物和人体健康有潜在风险。这篇综述对当前其可得的生物化学数据给出了一个关键的调查和解释,并推断其细胞效应。CYN被认为是一种细胞毒素。许多报道认为它是真核细胞蛋白合成的潜在抑制剂,尽管它的准确机制尚未完全为人类所知。在此我们发现由CYN引发的生物化学改变将更复杂,可能包括多种作用方式。除了先前提出的蛋白合成抑制,谷胱甘肽代谢和嘧啶核苷酸合成也受到了影响。在动植物内生物化学的改变导致了下列细胞/亚细胞改变:(i)因染色质和细胞骨架的微小改变引起的细胞裂分率的改变;(ii)包括内质网在内的内膜结构与功能的微小改变;(iii)一般代谢改变导致的基因毒性和细胞程序性死亡/凋亡。这篇综述对潜在机制和可能的健康后果进行了讨论。
关键词: Cylindrospermopsin,蓝细菌,蛋白合成,细胞循环,内膜,细胞骨架,细胞程序性死亡
Current Medicinal Chemistry
Title:Cellular Effects of Cylindrospermopsin (Cyanobacterial Alkaloid Toxin) and its Potential Medical Consequences
Volume: 24 Issue: 1
Author(s): Csaba Mathe, Márta M-Hamvas, Tamas Garda, Daniel Beyer, Gabor Vasas.
Affiliation:
关键词: Cylindrospermopsin,蓝细菌,蛋白合成,细胞循环,内膜,细胞骨架,细胞程序性死亡
摘要: Cylindrospermopsin (CYN) is a tricyclic guanidino alkaloid toxin produced by several cyanobacterial genera. It alters cellular functioning in eukaryotes, including animal and plant organisms. Over the past decades, more and more evidence shows its potential hazardous effects on animal and human health. In this review, we give a critical survey and interpretation of data currently available on its biochemical and consequently, cellular effects. CYN is considered to be a cytotoxin. Several reports suggest that it is a potent inhibitor of eukaryotic protein synthesis, though the exact mechanisms are not completely understood. Here we show that the biochemical changes induced by CYN are complex, possibly involving multiple modes of action. Glutathione metabolism and pyrimidine nucleotide synthesis is affected besides the proposed protein synthesis inhibition. Biochemical alterations lead to the following cellular/subcellular alterations both in animals and plants: (i) changes in cell division rates due to perturbations in chromatin and cytoskeleton; (ii) perturbations of structure and functioning of endomembranes including endoplasmic reticulum; (iii) general metabolic alterations leading to genotoxicity and programmed cell death/apoptosis. The underlying mechanisms and possible health consequences are discussed.
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Cite this article as:
Csaba Mathe, Márta M-Hamvas, Tamas Garda, Daniel Beyer, Gabor Vasas. , Cellular Effects of Cylindrospermopsin (Cyanobacterial Alkaloid Toxin) and its Potential Medical Consequences, Current Medicinal Chemistry 2017; 24 (1) . https://dx.doi.org/10.2174/0929867323666161028153814
DOI https://dx.doi.org/10.2174/0929867323666161028153814 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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