摘要
背景:白藜芦醇可能具有延长生命和健康有益的特性,其中一些可能像研究热量限制(CR)。CR出现延长模型生物的寿命在一些研究中,可能有利于人类健康。然而,对于人类而言,限制一段时间进食似乎不切实际,物质模仿CR的有利影响而不得不减少食物的摄入可以改善健康老龄化和肥胖人群。 方法:我们已经回顾了文献研究白藜芦醇对模型生物的寿命,包括酵母,苍蝇,蠕虫和啮齿动物的影响。我们总结了体内的研究结果,描述调制的分子靶标和基因表达在体内和体外观察,并讨论这些变化可能有助于寿命延长。从临床研究的数据进行了总结,提供了一个洞察白藜芦醇补充人类的潜力。 结果:白藜芦醇的补充已被证明延长寿命约60%的模型生物体进行的研究。然而,目前的文献是矛盾的,表明白藜芦醇的寿命的影响有很大的不同,这取决于模型生物。而蠕虫和鱼似乎很敏感的白藜芦醇,白藜芦醇没有影响的研究在果蝇和小鼠的寿命进行了大部分。此外,如剂量,性别,遗传背景和饮食组成的因素可能会导致观察到的效果的高方差。 结论:它仍然是不确定白藜芦醇是否确实是一个CR模拟具有延长生命的性质。白藜芦醇的生物利用度有限,可能进一步阻碍其潜在的影响。
关键词: 二苯乙烯,caloric longevity,能量限制的限制,mimetic,多酚,红酒。
Current Medicinal Chemistry
Title:Resveratrol and Lifespan in Model Organisms
Volume: 23 Issue: 41
Author(s): Kathrin Pallauf, Gerald Rimbach, Petra Maria Rupp, Dawn Chin, Insa M.A. Wolf
Affiliation:
关键词: 二苯乙烯,caloric longevity,能量限制的限制,mimetic,多酚,红酒。
摘要: Background: Resveratrol may possess life-prolonging and health-benefitting properties, some of which may resemble the effect of caloric restriction (CR). CR appears to prolong the lifespan of model organisms in some studies and may benefit human health. However, for humans, restricting food intake for an extended period of time seems impracticable and substances imitating the beneficial effects of CR without having to reduce food intake could improve health in an aging and overweight population.
Methods: We have reviewed the literature studying the influence of resveratrol on the lifespan of model organisms including yeast, flies, worms, and rodents. We summarize the in vivo findings, describe modulations of molecular targets and gene expression observed in vivo and in vitro, and discuss how these changes may contribute to lifespan extension. Data from clinical studies are summarized to provide an insight about the potential of resveratrol supplementation in humans.
Results: Resveratrol supplementation has been shown to prolong lifespan in approximately 60% of the studies conducted in model organisms. However, current literature is contradictory, indicating that the lifespan effects of resveratrol vary strongly depending on the model organism. While worms and killifish seemed very responsive to resveratrol, resveratrol failed to affect lifespan in the majority of the studies conducted in flies and mice. Furthermore, factors such as dose, gender, genetic background and diet composition may contribute to the high variance in the observed effects.
Conclusion: It remains inconclusive whether resveratrol is indeed a CR mimetic and possesses life-prolonging properties. The limited bioavailability of resveratrol may further impede its potential effects.
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Cite this article as:
Kathrin Pallauf, Gerald Rimbach, Petra Maria Rupp, Dawn Chin, Insa M.A. Wolf , Resveratrol and Lifespan in Model Organisms, Current Medicinal Chemistry 2016; 23 (41) . https://dx.doi.org/10.2174/0929867323666161024151233
DOI https://dx.doi.org/10.2174/0929867323666161024151233 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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