系统生物学和基因组学技术综述

Title:Overview of Systems Biology and Omics Technologies

Volume: 23 Issue: 37

Author(s): Bensu Karahalil

Affiliation:

关键词: 系统生物学，组学技术，基因组学，转录组学，蛋白组学，代谢组学

摘要: Traditional technologies using reductionist approach are relatively insufficient to solve problems in a biological system. Rather than a reductionist approach, systems biology uses a holistic and integrative approach to better figure out the whole process. Both qualitatively and quantitatively of biological system provide information about diseases, toxicities, therapies etc. Omics technologies, which systems biology brings, are valuable tools for comprehensive analyses. Automated DNA sequencers enabled the sequencing of genomes; microarray and mass spectrometry analysis permit global transcriptional profiling and lead to large-scale proteomic and metabolomics analysis. These high-throughput data need to be interpreted by bioinformatics. So far there has been no concrete published paper that compiles omics technologies according to PubMed database. In the present review, it was aimed to give brief description of systems biology and information on the advantages and disadvantages of omics technologies.

Cite this article as:

Bensu Karahalil , Overview of Systems Biology and Omics Technologies, Current Medicinal Chemistry 2016; 23 (37) . https://dx.doi.org/10.2174/0929867323666160926150617