Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv

Title:Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv

Volume: 17 Issue: 7

Author(s): Qi Li, Yan Zhang, Jun-Ling Shi*, Yi-Lin Wang, Hao-Bin Zhao, Dong-yan Shao, Qing-Sheng Huang, Hui Yang and Ming-Liang Jin

Affiliation:

• Key Laboratory for Space Bioscience and Space Biotechnology, School of Life Sciences, Northwestern Polytechnical University, Xi'an 710072, Shaanxi, People's,China

Keywords: Apoptosis, caspase, inhibition effects, pinoresinol, pinoresinol monoglucosid.

Abstract: Backgroud: Pinoresinol (Pin) and pinoresinol monoglucoside (PMG) are plant-derived lignan molecules with multiple functions. We showed previously that an endophytic fungus from Eucommia ulmoides Oliv., Phomopsis sp. XP-8 is able to produce Pin and PMG.

Objective: This study was carried out to test the anti-tumor capability of the culture of XP-8 and identify the major effective compounds.

Method: The fungal culture was added in the culture of HepG2 and K562 cells, and the viabilities of these cells were detected and the possible mechanism was analyzed.

Result: The fungal culture showed significant capaiblity in decreasing the viability of tumor cells and induce apoptosis via up-regulation of the expression of apoptosis-related genes. It also significantly inhibited the adhesion and migration of HepG2 cells by blocking MMP-9 expression. Pin and PMG were isolated from the growth culture and shown to be the major effective components for inhibition. Conclusion: The study indicated the potential application of XP-8 in the production of anti-tumour products by the bioconversion of glucose.

Cite this article as:

Li Qi, Zhang Yan, Shi Jun-Ling*, Wang Yi-Lin, Zhao Hao-Bin, Shao Dong-yan, Huang Qing-Sheng, Yang Hui and Jin Ming-Liang, Mechanism and Anticancer Activity of the Metabolites of an Endophytic Fungi from Eucommia ulmoides Oliv, Anti-Cancer Agents in Medicinal Chemistry 2017; 17 (7) . https://dx.doi.org/10.2174/1871520616666160923094814

DOI https://dx.doi.org/10.2174/1871520616666160923094814	Print ISSN 1871-5206
Publisher Name Bentham Science Publisher	Online ISSN 1875-5992