摘要
Leucine zipper和sterile-α motif kinase (Zak)是混合谱系激酶家族的一个成员(MLKs),它是不同的生理疾病的新靶点,包括心肌肥厚和心肌纤维化,炎症和癌症。然而,其生物功能和小分子抑制剂的进展是有限的。只有多激酶抑制剂被报道可以非选择性结合各种Zak还有许多潜在物。在此,我们提供了一个关于生物学功能和Zak小分子抑制剂最新的概述。
关键词: ZAK
Current Medicinal Chemistry
Title:Leucine-zipper and Sterile-α Motif Kinase (ZAK): A Potential Target for Drug Discovery
Volume: 23 Issue: 33
Author(s): Yu Chang, Qingwen Zhang, Zhengqiu Li, Ke Ding, Xiaoyun Lu
Affiliation:
关键词: ZAK
摘要: Leucine-zipper and sterile-α motif kinase (ZAK) is a member of mixed-lineage kinase family (MLKs), which is considered as a new potential target for different physiological disorders, including myocardial hypertrophy and cardiac fibrosis, inflammation and cancer. However, the progress on its biological functions and small molecule inhibitors is limited. Only several multi-kinases inhibitors are reported to non-selectively bind with ZAK with various potencies. Herein, we provide an updated overview on the biological functions and small molecular inhibitors of ZAKs.
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Cite this article as:
Yu Chang, Qingwen Zhang, Zhengqiu Li, Ke Ding, Xiaoyun Lu , Leucine-zipper and Sterile-α Motif Kinase (ZAK): A Potential Target for Drug Discovery, Current Medicinal Chemistry 2016; 23 (33) . https://dx.doi.org/10.2174/0929867323666160920104121
DOI https://dx.doi.org/10.2174/0929867323666160920104121 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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