摘要
背景:心血管疾病(CVD)是世界范围内发病率和死亡率的主要成因,严重影响患者的生活质量,造成巨大的经济和社会负担。众所周知,食素可能通过减轻一些危险因素和/或调节疾病的发病和发展减少心血管病的风险。植物的次生代谢产物丰富,是萜类化合物最丰富、结构多样的组。这些化合物表现出广阔的治疗潜力,抗菌,抗病毒,抗炎和抗肿瘤药物。尽管他们的知名度,但是萜类对心血管的影响的科学证据仍然稀少,限制其潜在作为保护和/或心脏病治疗药物的使用。 目的:牢记全面系统研究的不足,本综述的目的是收集的一些知识和积累的多年来对萜类化合物在心血管领域与心血管病即缺血性心脏病的作用,集中最科学证据的心力衰竭、心律失常及高血压。 方法:几种常用的搜索引擎包括PubMed、Science Direct、Scopus和谷歌学术咨询。书目研究主要集中在过去15年发表的英文书面论文。 结果:提供对萜类化合物对心血管的影响进行系统的,全面的更新。此外,众所周知,可能的作用机制相关的指出以及试图找出最相关的结构-活性关系的萜烯不同类别的心血管效应。 结论:总的来说,本文能够更好地了解萜类化合物的心血管效应,实现未来在药物化学和药物设计的研究。
关键词: 萜类,心血管,心脏病,低血压,血管舒张,构效关系
Current Medicinal Chemistry
Title:Protective Effects of Terpenes on the Cardiovascular System: Current Advances and Future Perspectives
Volume: 23 Issue: 40
Author(s): Jorge M. Alves-Silva, Monica Zuzarte, Carla Marques, Ligia Salgueiro, Henrique Girao
Affiliation:
关键词: 萜类,心血管,心脏病,低血压,血管舒张,构效关系
摘要: Background: Cardiovascular diseases (CVDs) are the leading cause of morbidity and mortality worldwide that seriously affect patient’s life quality and are responsible for huge economic and social burdens. It is widely accepted that a plant-based diet may reduce the risk of CVDs by attenuating several risk factors and/or modulating disease’s onset and progression. Plants are rich in secondary metabolites, being terpenes the most abundant and structurally diverse group. These compounds have shown broad therapeutic potential as antimicrobial, antiviral, anti-inflammatory and antitumor agents. Despite their popularity, scientific evidence on terpenes cardiovascular effects remains sparse, limiting their potential use as cardioprotective and/or cardiotherapeutic agents.
Objective: Bearing in mind the lack of comprehensive and systematic studies, the present review aims to gather the knowledge and some of the most scientific evidence accumulated over the past years on the effect of terpenes in the cardiovascular field with focus on CVDs namely ischemic heart disease, heart failure, arrhythmias and hypertension. Method: Several popular search engines including PubMed, Science Direct, Scopus and Google Scholar were consulted. The bibliographic research focused primarily on English written papers published over the last 15 years. Results: A systematic and comprehensive update on the cardiovascular effects of terpenes is provided. Moreover, whenever known, the possible mechanisms of action underlying the cardiovascular effects are pointed out as well as an attempt to identify the most relevant structure- activity relationships of the different classes of terpenes. Conclusion: Overall, this review enables a better understanding of the cardiovascular effects of terpenes, thus paving the way towards future research in medicinal chemistry and rational drug design.Export Options
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Cite this article as:
Jorge M. Alves-Silva, Monica Zuzarte, Carla Marques, Ligia Salgueiro, Henrique Girao , Protective Effects of Terpenes on the Cardiovascular System: Current Advances and Future Perspectives, Current Medicinal Chemistry 2016; 23 (40) . https://dx.doi.org/10.2174/0929867323666160907123559
DOI https://dx.doi.org/10.2174/0929867323666160907123559 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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