Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.

Title:Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L.

Volume: 13 Issue: 4

Author(s): Soumia Bouzidi, Naima Benkiki, Messaoud Hachemi and Hamada Haba*

Affiliation:

• Faculty of Matter Sciences, Department of Chemistry, Laboratory of Chemistry and Environmental Chemistry (L.C.C.E), Batna-1 University, Batna,Algeria

Keywords: Eryngium campestre, inflammation, pyrexia, antipyretic activity, anti-inflammatory activity, apiaceae, antioxidant activity.

Abstract: Objective: This study was accomplished to evaluate the in vitro antioxidant activity, in vivo antipyretic and the anti-inflammatory activities of the n-butanol extract of roots and aerial parts of Algerian Eryngium campestre L.

Materials and Methods: The antioxidant properties were tested using DPPH radical scavenging and β- Carotene linoleic acid of various extracts from roots and aerial parts of E. campestre L., total phenolic and flavonoid contents were also determined. Furthermore, the anti-inflammatory and antipyretic activities of the n-butanol extracts were investigated on female wistar rats at the dose levels of 250 and 500 mg/kg body weight, using the egg albumin induced oedema and brewer’s yeast induced pyrexia method respectively.

Results: n-butanol extract of aerial parts had considerably higher antiradical activity with IC50 value of 16.140 µg/ml, and a good anti-inflammatory activity comparable to the standard drug diclofenac. Also, the n-butanol extract of roots possessed a better antipyretic effect (at both dose 250 mg/kg and 500 mg/kg) compared to the n-butanol extract of aerial parts.

Conclusion: These results suggested that Eryngium campestre L. could be used to treat various inflammatory diseases.

Cite this article as:

Bouzidi Soumia, Benkiki Naima, Hachemi Messaoud and Haba Hamada*, Investigation of In Vitro Antioxidant Activity and In Vivo Antipyretic and Anti-Inflammatory Activities of Algerian Eryngium campestre L., Current Bioactive Compounds 2017; 13 (4) . https://dx.doi.org/10.2174/1573407212666160815124204

DOI https://dx.doi.org/10.2174/1573407212666160815124204	Print ISSN 1573-4072
Publisher Name Bentham Science Publisher	Online ISSN 1875-6646