摘要
NO敏感的鸟苷酸环化酶(NO-GC)作为一氧化氮的受体,通过增加cGMP来调节NO在心血管和神经系统中的作用。两种NO-GC亚型的存在并没有引起太大的重视,因为他们揭示了类似的监管和催化性能,因此在体内也不能分化。在某个亚型的基因被敲除的小鼠模型中,NO-GC1和NO-GC2在除血小板的所有组织中都有表达。目前为止,除了脑和血小板的组织,没有什么特别的功能可以归因于一个特定的NO-GC亚型。相反,NO-GC1和NO-GC12在中央神经系统扮演着不同角色。NO-GC1的突触前作用和NO-GC12的突触后作用。有研究表明两种NO/cGMP信号途径在突触间隙的两侧增强突触传递的强度。
关键词: 一氧化氮,cGMP,鸟苷酸环化酶,基因敲除,平滑肌张力、血压、抑制血小板聚集、突触传递
Current Medicinal Chemistry
Title:Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms
Volume: 23 Issue: 24
Author(s): Doris Koesling, Evanthia Mergia, Michael Russwurm
Affiliation:
关键词: 一氧化氮,cGMP,鸟苷酸环化酶,基因敲除,平滑肌张力、血压、抑制血小板聚集、突触传递
摘要: NO-sensitive guanylyl cyclase (NO-GC) acts as the receptor for nitric oxide and by the increase in cGMP executes most of the NO effects in the cardiovascular and neuronal system. Two isoforms of NO-GC exist whose existence has not been paid much attention to probably because they reveal comparable regulatory and catalytic properties and therefore cannot be differentiated in vivo. Analysis of mice in which either one of the isoforms has been genetically deleted unequivocally establishes the coexpression of NO-GC1 and NOGC2 in any tissue tested to date with the exception of platelets. In tissues other than brain and platelets, no particular function could be ascribed to a specific NO-GC isoform so far. In contrast, NO-GC1 and NO-GC2 serve different functions in the central nervous system. With NO-GC1's presynaptic role and NO-GC2's postsynaptic action, two NO/cGMP pathways have been shown to exist that enhance the strength of synaptic transmission on either side of the synaptic cleft.
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Cite this article as:
Doris Koesling, Evanthia Mergia, Michael Russwurm , Physiological Functions of NO-Sensitive Guanylyl Cyclase Isoforms, Current Medicinal Chemistry 2016; 23 (24) . https://dx.doi.org/10.2174/0929867323666160812145050
DOI https://dx.doi.org/10.2174/0929867323666160812145050 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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