摘要
背景:真菌感染已经在所有年龄组中造成严重问题,特别是在免疫受损的个体中。各种合成试剂正在临床实践中用于治疗这些感染,然而,对这些试剂的抗性严重影响了它们的治疗质量。 目的:本综述重点介绍天然生物碱的抗真菌活性,其来源,化学结构和效力以及可能的作用机制。 结果:现有文献的结果表明,至少70种不同的植物源生物碱体外具有抗真菌活性。这些生物碱是从不同的植物和家庭中分离出来的,这些植物在植物界有着不同的分布。另外,来自各种类别的生物碱描绘了针对各种真菌的抗真菌作用。 结论:生物碱可能是一种更好的治疗方法,可用的治疗方法的抵抗机会较少,但在最终建议之前还需要更多的研究和临床试验。此外,本次审查提供的细节将提供更多的关于天然生物碱作为抗真菌剂展现出的良好承诺的意识。
关键词: 生物碱,抗真菌活性,结构和效力,抗真菌药物,机制,替代药物,未来的药物。
图形摘要
Current Drug Targets
Title:Antifungal Potential of Alkaloids As An Emerging Therapeutic Target
Volume: 18 Issue: 16
关键词: 生物碱,抗真菌活性,结构和效力,抗真菌药物,机制,替代药物,未来的药物。
摘要: Background: Fungal infections have been causing serious problems in all age groups, especially in immune-compromised individuals. Various synthetic agents are in clinical practice for the treatment of these infections, however, resistance to these agents badly affected their therapeutic quality.
Objective: This review focuses on the antifungal activity of naturally occurring alkaloids, their source, chemical structure, and potency with a possible mechanism(s) of action.
Results: The results of available literature showed that at least 70 different plant derived alkaloids exhibited antifungal activity in vitro. These alkaloids are isolated from different plants and families showing their diverse distribution in plant kingdom. Additionally, the alkaloid from various classes depicted antifungal effects against a variety of fungi.
Conclusions: Alkaloids could be a better therapeutic alternative to available therapies with fewer chances of resistance but more research and clinical trials are needed before final recommendations. Additionally, the details provided in this review will offer greater awareness of the excellent promise that natural alkaloids exhibit as antifungal agents.
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Cite this article as:
Antifungal Potential of Alkaloids As An Emerging Therapeutic Target, Current Drug Targets 2017; 18 (16) . https://dx.doi.org/10.2174/1389450117666160719095517
DOI https://dx.doi.org/10.2174/1389450117666160719095517 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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