摘要
人类的皮肤癌约占所有新发癌症的30%,是目前为止白种人中最常见的恶行肿瘤。暴露于放射物(特别是UV-B辐射),连同其它化学和生物因素,是引起皮肤癌的主要原因。正在上升的全球皮肤癌发病率,说明了新可选疗法的需求。根据皮肤癌病因学与发病机制,研发出对抗这种普遍性疾病的有效药物是至关重要的。药用植物富含多种次生代谢产物如黄酮类次生代谢产物,目前已知它能治疗多种慢性疾病,如炎症和癌症。黄酮类次生代谢产物可以细分为黄酮、黄酮醇、异黄酮、黄烷酮、黄烷醇和花青素。它们作用于不同的靶点,包括活性氧簇的清除、细胞循环的调节、DNA修复机制的启动、细胞凋亡的诱发和转移抑制。无数证据证明多食用富含黄酮类代谢产物的水果与蔬菜给暴露于致癌物(如UV-B辐射)的正常皮肤提供DNA保护作用。黄酮类代谢产物也表现出了诱导黑素瘤(皮肤病最可怕的一种形式)细胞凋亡的可能性。这篇综合类综述阐述了黄酮类次生代谢产物和它们关于炎症和皮肤癌管理的作用机制。
关键词: 皮肤癌, 炎症, 黄酮类次生代谢产物,化学预防, 作用机制,致癌物
Current Medicinal Chemistry
Title:Mechanism of Action of Flavonoids in Prevention of Inflammation- Associated Skin Cancer
Volume: 23 Issue: 32
Author(s): Vazhappilly Cijo George, Vijayabhavanath Vijayakumaran Vijesh, Dehigaspege Inoka Madumani Amararathna, Chelakkot Ayshwarya Lakshmi, Kannan Anbarasu, Devanga Ragupathi Naveen Kumar, Kannatt Radhakrishnan Ethiraj and Rangasamy Ashok Kumar, H. P. Vasantha Rupasinghe
Affiliation:
关键词: 皮肤癌, 炎症, 黄酮类次生代谢产物,化学预防, 作用机制,致癌物
摘要: Skin cancer in humans represents about 30% of all new cancers and is by far the most common malignancy in the Caucasian population. Exposure to radiations especially ultraviolet-B (UV-B) radiation is the major cause for development of skin cancers along with other chemical or biological factors. The growing incidence rates of skin cancer around the world, demand the need for new treatment options. Understanding the etiology and pathogenesis of skin cancer is therefore crucial for developing an effective drug against this prevailing disease. Medicinal plants are rich with numerous secondary metabolites such as flavonoids, which are now known to treat various chronic diseases, including inflammations and cancers. Flavonoids are sub-classified in to flavones, flavonols, iosflavones, flavanones, flavanols and anthocyanidins. They act on different targets including scavenging reactive oxygen species (ROS), regulation of the cell cycle, and initiation of DNA repair mechanisms, apoptotic induction and inhibition of metastasis. Innumerable evidence suggested that an increased consumption of flavonoid-rich fruits and vegetables rendered DNA protection to normal skin exposed to carcinogens such as UV-B radiation. Flavonoids also showed the potential to induce cell death mechanisms in melanoma, the most dreadful form of skin cancer. This comprehensive review presents flavonoids and their mechanism of action in relation to inflammation and skin cancer management.
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Vazhappilly Cijo George, Vijayabhavanath Vijayakumaran Vijesh, Dehigaspege Inoka Madumani Amararathna , Chelakkot Ayshwarya Lakshmi, Kannan Anbarasu, Devanga Ragupathi Naveen Kumar, Kannatt Radhakrishnan Ethiraj and Rangasamy Ashok Kumar, H. P. Vasantha Rupasinghe , Mechanism of Action of Flavonoids in Prevention of Inflammation- Associated Skin Cancer, Current Medicinal Chemistry 2016; 23 (32) . https://dx.doi.org/10.2174/0929867323666160627110342
DOI https://dx.doi.org/10.2174/0929867323666160627110342 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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