Spirooxindoles as Potential Pharmacophores

Title:Spirooxindoles as Potential Pharmacophores

Volume: 17 Issue: 16

Author(s): Siva S. Panda*, Rachel A. Jones, Praveen Bachawala and Prabhu P. Mohapatra

Affiliation:

• Department of Chemistry & Physics, Augusta University, Augusta, GA 30912,United States

Keywords: Biological importance, chemistry, heterocycles, pharmacophores, spirooxindoles, synthesis.

Abstract: Objective: The spirooxindole heterocyclic scaffold is found in many natural products and has been identified as an important bioactive agent.

Background: Over the past few decades, various spirooxindole-containing compounds have been reported to possess biological properties and hence found in the structure of many synthetic pharmaceuticals.

This mini-review describes the most promising examples of this class of compounds possessing biological activity including anticancer, anti-inflammatory, and antimicrobial activities.

Conclusion: The current review focuses on the biological activity of compounds containing the spirooxindole scaffold.

Cite this article as:

Panda S. Siva *, Jones A. Rachel , Bachawala Praveen and Mohapatra P. Prabhu , Spirooxindoles as Potential Pharmacophores, Mini-Reviews in Medicinal Chemistry 2017; 17 (16) . https://dx.doi.org/10.2174/1389557516666160624125108