摘要
预计到2020年,美国胰腺癌将成为第二个最致命的恶性肿瘤(中位生存期为4-6个月,5年生存率低于5%)。虽然目前的医学检测技术已大大提高了患者的生存率与其他胃肠道恶性肿瘤相比,胰腺癌患者的惨淡临床结果仍然有些不变。临床前证据表明,除手术外,胰腺癌可能受益于早期全身治疗。新的生物标志物应该有助于确定这些患者可能是各种全身治疗的候选者,包括化疗。经典的抗癌药物如FOLFIRINOX(亚叶酸,5-氟尿嘧啶,伊立替康和奥沙利铂),以及nabpaclitaxel和吉西他滨仅在生存方面产生了一些适度的改善。为此,寻求胰腺癌的新治疗途径。这篇小型综述总结了胰腺癌治疗的最新技术,以及自噬在胰腺癌治疗中的可能作用
关键词: 自噬,胰腺癌,治疗学,胃肠道肿瘤,糖尿病,发病机制。
图形摘要
Current Drug Targets
Title:Pancreatic Neoplasms and Autophagy
Volume: 19 Issue: 9
关键词: 自噬,胰腺癌,治疗学,胃肠道肿瘤,糖尿病,发病机制。
摘要: Pancreatic cancer is predicted to be the second deadliest malignancy (a median survival of 4-6 months and a 5-year survival of less than 5%) in the USA by 2020. Although current medical detection technologies have dramatically improved the survival rate for patients with other gastrointestinal malignancies, the dismal clinical outcome remains somewhat unchanged for patients with pancreatic cancer. Preclinical evidence suggests that pancreatic cancer may be benefited from early administration of systemic therapy in addition to surgery. New biomarkers should help to identify those patients possibly candidates for various systemic therapy including chemotherapy. Classical anticancer drugs such as FOLFIRINOX (folinic acid, 5-fluorouracil, irinotecan, and oxaliplatin), and nabpaclitaxel plus gemcitabine only produced some modest improvements in survival. To this end, novel therapeutic avenues are sought for pancreatic cancer. This mini-review summarizes the state-of-the-art of pancreatic cancer treatment, and possible role of autophagy in therapeutics against pancreatic cancer.
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Cite this article as:
Pancreatic Neoplasms and Autophagy, Current Drug Targets 2018; 19 (9) . https://dx.doi.org/10.2174/1389450117666160622220915
DOI https://dx.doi.org/10.2174/1389450117666160622220915 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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