摘要
一直被认为是中枢神经系统(CNS)的支持细胞的小胶质细胞,现在被认识到在许多疾病中发挥重要作用。在过去的几十年里的许多研究表明,神经免疫相互作用是神经性疼痛的产生和维持的基础。通过大量的受体和信号转导通路,小胶质细胞与神经元、星形胶质细胞和其他细胞,包括免疫系统交换信息。中枢神经系统稳态的干扰或损失导致小胶质细胞的快速反应,使之经历了一个多阶段的激活过程。活化的小胶质细胞改变细胞形态和基因表达序列,从而诱导增殖,迁移,生产促进或抑制因素。细胞释放大量的介质,可以以对周围的细胞不利或有利,并可以间接地改变伤害性信号。本文综述了小胶质细胞内最重要的信号传导通路(MAPK和NF-κB,JAK/STAT,PI3K/Akt),对神经病理性疼痛的发生和维护是必不可少的。我们的目标是确定新的分子靶点,此分子靶点可能会导致控制与神经性疼痛相关的信号强大的工具的发展。
关键词: 小胶质细胞
Current Medicinal Chemistry
Title:Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain
Volume: 23 Issue: 26
Author(s): Katarzyna Popiolek-Barczyk, Joanna Mika
Affiliation:
关键词: 小胶质细胞
摘要: The microglia, once thought only to be supporting cells of the central nervous system (CNS), are now recognized to play essential roles in many pathologies. Many studies within the last decades indicated that the neuro-immune interaction underlies the generation and maintenance of neuropathic pain. Through a large number of receptors and signaling pathways, the microglial cells communicate with neurons, astrocytes and other cells, including those of the immune system. A disturbance or loss of CNS homeostasis causes rapid responses of the microglia, which undergo a multistage activation process. The activated microglia change their cell shapes and gene expression profiles, which induce proliferation, migration, and the production of pro- or antinociceptive factors. The cells release a large number of mediators that can act in a manner detrimental or beneficial to the surrounding cells and can indirectly alter the nociceptive signals. This review discusses the most important microglial intracellular signaling cascades (MAPKs, NF-κB, JAK/STAT, PI3K/Akt) that are essential for neuropathic pain development and maintenance. Our objective was to identify new molecular targets that may result in the development of powerful tools to control the signaling associated with neuropathic pain.
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Katarzyna Popiolek-Barczyk, Joanna Mika , Targeting the Microglial Signaling Pathways: New Insights in the Modulation of Neuropathic Pain, Current Medicinal Chemistry 2016; 23 (26) . https://dx.doi.org/10.2174/0929867323666160607120124
DOI https://dx.doi.org/10.2174/0929867323666160607120124 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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