摘要
背景:大麻的治疗效果自古以来就很出名。内源性大麻素系统(ECS)调节存在着越来越多与人类肿瘤发生相关的调制的证据。 目的:考虑到内皮细胞对免疫细胞调节的重要作用,本研究旨在总结出现过的有关的大麻素受体(CBR)和大麻素配体作用于血液系统恶性肿瘤中的表达。 结论:大多数大麻的行为对造血系统恶性细胞介导的主要规律很有潜力,作为细胞增殖和凋亡的诱导和抑制非凋亡性细胞程序性死亡已记录在册了。大麻素配体激活细胞生存的基本途径,如ERK、JNK、p38 MAPK以及诱导体外半胱天冬酶合成等。这些数据强烈被推荐并证实了大麻素配体的生物利用度和phytocannabinoid作用于神经的属性。初步的抗肿瘤作用及其相对缺乏的重要副作用,使内皮细胞治疗血液系统恶性肿瘤成为一种很有前途的治疗目标。
关键词: 大麻;大麻受体;内源性大麻素系统;血液系统恶性肿瘤;白血病;淋巴瘤。
Current Medicinal Chemistry
Title:Endocannabinoid System: A Promising Therapeutic Target for the Treatment of Haematological Malignancies?
Volume: 23 Issue: 22
Author(s): Constantinos Giaginis, Eleftheria Lakiotaki, Penelope Korkolopoulou, Konstantinos Konstantopoulos, Efstratios Patsouris and Stamatios Theocharis
Affiliation:
关键词: 大麻;大麻受体;内源性大麻素系统;血液系统恶性肿瘤;白血病;淋巴瘤。
摘要: Background: The therapeutic properties of cannabinoids are well-known since ancient years. Growing evidence exist on endocannabinoid system (ECS) modulation related with human tumorigenesis.
Objective: Taking into account the substantial role of ECS on immune cell regulation, the present review is aimed to summarize the emerging evidence concerning cannabinoid receptor (CBR) expression and cannabinoid ligand effects on haematological malignancies.
Conclusions: Most of cannabinoid actions, mainly CB2R-mediated against haematopoietic malignant cells, seem promising, as inhibition of cell proliferation and apoptosis and paraptosis induction have been documented. Cannabinoid ligands appear to activate rudimentary pathways for cell survival, such as ERK, JNK, p38 MAPK, and to induce caspase synthesis, in vitro. Such data are strongly recommended to be confirmed by in vivo experiments with emphasis on cannabinoid ligands’ bioavailability and phytocannabinoid psychotropic properties. The preliminary antitumoral ECS effects and their relative lack of important side effects render ECS a promising therapeutic target for the treatment of haematological malignancies.
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Constantinos Giaginis, Eleftheria Lakiotaki, Penelope Korkolopoulou, Konstantinos Konstantopoulos, Efstratios Patsouris and Stamatios Theocharis , Endocannabinoid System: A Promising Therapeutic Target for the Treatment of Haematological Malignancies?, Current Medicinal Chemistry 2016; 23 (22) . https://dx.doi.org/10.2174/0929867323666160530144934
DOI https://dx.doi.org/10.2174/0929867323666160530144934 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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