从植物中提取的倍半萜内酯类抗癌药物的发展

Title:Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones

Volume: 23 Issue: 23

Author(s): Yulin Ren, Jianhua Yu, A. Douglas Kinghorn

Affiliation:

关键词: 青蒿素；二聚体青蒿素；dimethylaminoparthenolide；小白菊内酯二聚体；潜在的抗癌药物；倍半萜内酯；胡萝卜素内酯。

摘要: Sesquiterpene lactones are of considerable interest due to their potent bioactivities, including cancer cell cytotoxicity and antineoplastic efficacy in in vivo studies. Among these compounds, artesunate, dimethylaminoparthenolide, and L12ADT peptide prodrug, a derivative of thapsigargin, are being evaluated in the current cancer clinical or preclinical trials. Based on the structures of several antitumor sesquiterpene lactones, a number of analogues showing greater potency have been either isolated as natural products or partially synthesized, and some potential anticancer agents that have emerged from this group of lead compounds have been investigated extensively. The present review focuses on artemisinin, parthenolide, thapsigargin, and their naturally occurring or synthetic analogues showing potential anticancer activity. This provides an overview of the advances in the development of these types of sesquiterpene lactones as potential anticancer agents, including their structural characterization, synthesis and synthetic modification, and antitumor potential, with the mechanism of action and structure-activity relationships also discussed. It is hoped that this will be helpful in stimulating the further interest in developing sesquiterpene lactones and their derivatives as new anticancer agents.

Cite this article as:

Yulin Ren, Jianhua Yu, A. Douglas Kinghorn , Development of Anticancer Agents from Plant-Derived Sesquiterpene Lactones, Current Medicinal Chemistry 2016; 23 (23) . https://dx.doi.org/10.2174/0929867323666160510123255