摘要
中枢神经系统(CNS)肿瘤包括脑肿瘤和脊髓。考虑到细胞类型的来源,几乎存在着120种不同类型的中枢神经系统肿瘤。良性肿瘤是不具侵袭性的,通常不侵入其他器官,但是,他们需要被手术切除,因为他们会改变周围的脑功能。原发性恶性脑肿瘤通常包括星形细胞瘤,少突胶质细胞瘤和ependimomas,其中星形细胞瘤占76%左右。世界卫生组织(WHO)已经规定了四种级别的星形细胞瘤,从低侵袭性的肿瘤(I级)到高度恶性肿瘤(IV级)。这些IV级肿瘤,又称胶质母细胞瘤(GBM),是原发性恶性脑肿瘤中最具侵袭性的。GBM患者的一般生存期为12个月至15个月。GBM目前的治疗包括手术、放疗和化疗。虽然有诊断和治疗方面的进展,但目前还没有可用于胶质母细胞瘤的最佳治疗选择。在本文中,我们将讨论对于胶质瘤的诊断及治疗方法,特别关注治疗后影像学,以及新的靶向治疗是否对GBM患者生存率有影响。此外,我们将讨论临床试验和关于胶质母细胞瘤的诊断和治疗的未来。
关键词: 胶质母细胞瘤;GBM;诊断;治疗;临床试验;放疗;替莫唑胺。
Current Molecular Medicine
Title:Diagnosis and New Treatment Modalities for Glioblastoma: Do They Improve Patient Survival?
Volume: 16 Issue: 5
Author(s): R. Alcedo-Guardia, E. Labat, D. Blas-Boria, P.E. Vivas-Mejia
Affiliation:
关键词: 胶质母细胞瘤;GBM;诊断;治疗;临床试验;放疗;替莫唑胺。
摘要: Central nervous system (CNS) malignances include tumors of the brain and spinal cord. Taking into account the cell type where they originate from, there are almost 120 different types of CNS tumors. Benign tumors are not aggressive and normally do not invade other organs; however, they require surgical removal before they alter the surrounding brain functions. Primary malignant brain tumors commonly include astrocytomas, oligodendrogliomas, and ependimomas, where astrocytomas represent around 76%. The World Health Organization (WHO) has defined four histological grades of astrocytomas that range from the less aggressive tumors (grade I) to highly malignant tumors (grade IV). These grade IV tumors, also called glioblastoma (GBM), are the most aggressive of the primary malignant brain tumors. Patients with GBM have a median survival of 12 to 15 months. Current treatment for GBM includes surgery, radiotherapy and chemotherapy. Although there have been some advances in diagnosis and treatment, there is still no optimal treatment available for GBMs. In this review, we will discuss the approaches for GBM diagnosis and treatment, with a special emphasis on post-treatment imaging, and whether novel targeted therapies have impacted the survival of GBM patients. In addition, we will discuss clinical trials and the future of GBM diagnosis and treatment.
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Cite this article as:
R. Alcedo-Guardia, E. Labat, D. Blas-Boria, P.E. Vivas-Mejia , Diagnosis and New Treatment Modalities for Glioblastoma: Do They Improve Patient Survival?, Current Molecular Medicine 2016; 16 (5) . https://dx.doi.org/10.2174/1566524016666160429120150
DOI https://dx.doi.org/10.2174/1566524016666160429120150 |
Print ISSN 1566-5240 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5666 |
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