Abstract
Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, hemorrhoids and diarrhea.
Methods: In this study, antibacterial, antioxidant, toxicity, acetylcholinesterase and - glucosidase inhibitory activities of several extracts of S. santolinifolia were evaluated. Total phenol and flavonoid contents of the extracts were also determined.
Results: The MeOH extract showed high antioxidant activity in DPPH scavenging and ferric reducing power assays. All samples exhibited high acetylcholinesterase (IC50 = 42-89 g/ml) and -glucosidase inhibitory activities (IC50 = 24-174 g/ml). The MeOH extract showed great antibacterial and antifungal activities especially against Bacillus cereus and Candida albicans with MIC values from 10 to 200 g/ml.
Conclusion: Our findings indicated that S. santolinifolia is a rich source of natural compounds with strong antimicrobial, antidiabetic and anti-Alzheimer activities. This plant has great potential for several applications as pharmaceuticals and functional foods.
Keywords: Salvia, diabetes mellitus, alzheimer, antioxidant, antimicrobial, phenolic compounds.
Graphical Abstract
Current Bioactive Compounds
Title:Biological Activities of Salvia santolinifolia Boiss. A Multifunctional Medicinal Plant
Volume: 12 Issue: 4
Author(s): Mir Babak Bahadori, Hassan Valizadeh, Behvar Asghari, Leila Dinparast, Shahram Bahadori and Mahdi Moridi Farimani
Affiliation:
Keywords: Salvia, diabetes mellitus, alzheimer, antioxidant, antimicrobial, phenolic compounds.
Abstract: Background: Salvia species are used traditionally for treatment of many disorders all around the world. Salvia santolinifolia is a medicinal plant, traditionally used for treatment of inflammation, hypercholesterolemia, hemorrhoids and diarrhea.
Methods: In this study, antibacterial, antioxidant, toxicity, acetylcholinesterase and - glucosidase inhibitory activities of several extracts of S. santolinifolia were evaluated. Total phenol and flavonoid contents of the extracts were also determined.
Results: The MeOH extract showed high antioxidant activity in DPPH scavenging and ferric reducing power assays. All samples exhibited high acetylcholinesterase (IC50 = 42-89 g/ml) and -glucosidase inhibitory activities (IC50 = 24-174 g/ml). The MeOH extract showed great antibacterial and antifungal activities especially against Bacillus cereus and Candida albicans with MIC values from 10 to 200 g/ml.
Conclusion: Our findings indicated that S. santolinifolia is a rich source of natural compounds with strong antimicrobial, antidiabetic and anti-Alzheimer activities. This plant has great potential for several applications as pharmaceuticals and functional foods.
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Cite this article as:
Bahadori Mir Babak, Valizadeh Hassan, Asghari Behvar, Dinparast Leila, Bahadori Shahram and Farimani Moridi Mahdi, Biological Activities of Salvia santolinifolia Boiss. A Multifunctional Medicinal Plant, Current Bioactive Compounds 2016; 12 (4) . https://dx.doi.org/10.2174/1573407212666160426161112
DOI https://dx.doi.org/10.2174/1573407212666160426161112 |
Print ISSN 1573-4072 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6646 |
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