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当代肿瘤药物靶点

Editor-in-Chief

ISSN (Print): 1568-0096
ISSN (Online): 1873-5576

Research Article

在ER阳性乳腺癌中,CYR61使芳香化酶抑制剂letrozole具有敏感性,

作者: Xiaoqing Jia, Guangyu Liu, Jingyi Cheng, Zhenzhou Shen, Zhimin Shao.

卷 17, 期 2, 2017

页: [191 - 197] 页: 7

弟呕挨: 10.2174/1568009616666160426125058

价格: $65

摘要

背景:有研究表明,富含半胱氨酸蛋白61(Cyr61)可能与肿瘤细胞的增殖和侵袭有关。然而,其在内分泌治疗反应中起的作用很大程度上是未知的。 患者和方法:我们检测了36例原发性乳腺癌患者CYR61表达水平,这些患者在服用letrozole之前或之后接受至少3个月的辅助内分泌治疗。其中,letrozole是用于治疗激素反应性乳腺癌的口服非甾体芳香酶抑制剂。采用配对t检验对处理前和处理后样品的Cyr61和Ki67表达水平进行比较。采用卡方检验测定基线CYR61表达与临床反应之间的关系。 结果:在临床病例分析,基线CYR61表达与临床预后之间呈正相关(P = 0.02)。与基线活检标本相比,治疗后,残余肿瘤(表示对内分泌治疗不敏感)CYR61表达明显增加,这与原发性内分泌治疗的疗效无关。另外,与基线样品相比,Ki67水平在辅助内分泌治疗后明显下降。 结论:本研究证实Cyr61可能赋予了来曲唑的敏感性,以 Cyr61为靶点能改善ER阳性乳腺癌的内分泌抵抗。

关键词: 芳香化酶抑制剂,乳腺癌,CYR61/CNN1,雌激素受体,敏感性

图形摘要

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