Electrochemical Behavior of Melatonin and its Sensing in Pharmaceutical Formulations and in Human Urine

Title:Electrochemical Behavior of Melatonin and its Sensing in Pharmaceutical Formulations and in Human Urine

Volume: 13 Issue: 1

Author(s): Neeraj Kumar and Rajendra N. Goyal

Affiliation:

Keywords: Melatonin, glassy carbon electrode, voltammetry, oxidation, human urine.

Abstract:

Introduction: A simple, sensitive and reliable sensor has been explored for the determination of Melatonin (MEL) using cyclic voltammetry (CV) and square wave voltammetry (SWV).

Method: Irreversible oxidation of MEL was found to proceed through an adsorption controlled pathway at the glassy carbon electrode. The quantitative estimation of MEL was performed using SWV in a linear concentration range of 5-200 µM with a sensitivity of 0.0437 µM/ µA and a limit of detection of 0.3432 µM. The proposed protocol was also applied for determining MEL content in pharmaceutical samples and recovery studies in human urine samples were also performed.

Result: The observed results demonstrated a good agreement with the stated values.

Cite this article as:

Kumar Neeraj and Goyal N. Rajendra, Electrochemical Behavior of Melatonin and its Sensing in Pharmaceutical Formulations and in Human Urine, Current Pharmaceutical Analysis 2017; 13 (1) . https://dx.doi.org/10.2174/1573412912666160422154459