微波辅助生成有机二硫化物的生物学意义

Title:Microwave-assisted Formation of Organic Disulfides of Biochemical Significance

Volume: 24 Issue: 41

关键词: 二硫化物，微波，具有S-S键的肽，硫醇，固相肽合成，有机化合物。

摘要: Organic compounds possessing the –S–S– bond, often called disulfide or disulfane, are extremely important and useful in various fields. They often exhibit unique and diverse chemistry in synthetic, biochemical, pharmacological areas as well as are vastly used as vulcanizing agents for rubbers and elastomers. In peptide and protein chemistry, the disulfide bridges impart stability in folding and their synthesis is a pivotal transformation in modern medicinal chemistry research. On the other hand, microwave (MW) provides heat energy source, an alternative to conventional heating, and is used for diverse chemical reactions. This review has presented the progress towards the synthesis of small organic disulfanes and acyclic/cyclic peptides bearing the –S–S– bond specifically under microwave irradiation, which often facilitated the formation of disulfides over conventional heating both in terms of reaction time and efficiency.

Cite this article as:

Microwave-assisted Formation of Organic Disulfides of Biochemical Significance, Current Medicinal Chemistry 2017; 24 (41) . https://dx.doi.org/10.2174/0929867323666160418115719