Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy

Title:Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy

Volume: 16 Issue: 30

Author(s): Richa Goel, Vijay Luxami and Kamaldeep Paul

Affiliation:

Keywords: Antitubulins, Antitumor, Cyclin dependent kinase inhibitors, Imidazo[1, 2-a]pyridine, Phosphoinositide-3-kinase inhibitors, Topoisomerase-II inhibitors.

Abstract: Imidazo[1,2-a]pyridine has been shown to be an important biologically active moiety. This review is a compilation of the scattered output of results of the anticancer activities of the imidazo[1,2-a]pyridine system since 2001, which have been classified as inhibition of CDK, VEGFR, PI3K, EGFR, RGGT etc. along with inhibition against different tumor cell lines. Various imidazo[1,2-a]pyridine based analogues have been used as lead molecules and are now under human clinical trials. This review will help the wider scientific community in the area of drug discovery of imidazo[1,2-a]pyridines as novel anticancer agents.

Cite this article as:

Goel Richa, Luxami Vijay and Paul Kamaldeep, Imidazo[1,2-a]pyridines: Promising Drug Candidate for Antitumor Therapy, Current Topics in Medicinal Chemistry 2016; 16 (30) . https://dx.doi.org/10.2174/1568026616666160414122644