摘要
ATP binding cassette (ABC)参与药物吸收、分布和消除。他们还介导了多药耐药的癌细胞。异黄酮类化合物,如染料木素(GNT),是一类天然存在的化合物,高浓度存在于普遍食用的大豆为基础的食品和膳食补充剂。GNT及其代谢产物与ABC转运蛋白作为底物相互作用,以及抑制剂和调制器的表达。本文综述收集了关于ABC转运蛋白通过调节GNT对ABC转运蛋白在尿内三大集团特别强调和外源性物质,具体如下:P糖蛋白(MDR1,ABCB1),一组多药耐药相关蛋白(MRPs, ABCC subfamily)和ABCG2(BCRP),ABC半转运。美国进一步考虑这些法规对潜在药物相互作用的影响。
关键词: ATP结合盒转运体,乳腺癌耐药蛋白、染料木素、多药耐药相关蛋白,营养药物相互作用,P-糖蛋白,外源性运输。
Current Medicinal Chemistry
Title:Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition
Volume: 23 Issue: 13
Author(s): Juan Pablo Rigalli, Nadia Ciriaci, Aldo Domingo Mottino, Viviana Alicia Catania, María Laura Ruiz
Affiliation:
关键词: ATP结合盒转运体,乳腺癌耐药蛋白、染料木素、多药耐药相关蛋白,营养药物相互作用,P-糖蛋白,外源性运输。
摘要: ATP binding cassette (ABC) transporters are involved in drug absorption, distribution and elimination. They also mediate multidrug resistance in cancer cells. Isoflavones, such as genistein (GNT), belong to a class of naturally-occurring compounds found at high concentrations in commonly consumed soya based-foods and dietary supplements. GNT and its metabolites interact with ABC transporters as substrates, inhibitors and/or modulators of their expression. This review compiles information about regulation of ABC transporters by GNT with special emphasis on the three major groups of ABC transporters involved in excretion of endo- and xenobiotics as follows: Pglycoprotein (MDR1, ABCB1), a group of multidrug resistance associated proteins (MRPs, ABCC subfamily) and ABCG2 (BCRP), an ABC half-transporter. The impact of these regulations on potential GNT-drug interactions is further considered.
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Cite this article as:
Juan Pablo Rigalli, Nadia Ciriaci, Aldo Domingo Mottino, Viviana Alicia Catania, María Laura Ruiz , Modulation of Expression and Activity of ABC Transporters by the Phytoestrogen Genistein. Impact on Drug Disposition, Current Medicinal Chemistry 2016; 23 (13) . https://dx.doi.org/10.2174/0929867323666160406120711
DOI https://dx.doi.org/10.2174/0929867323666160406120711 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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