摘要
背景:纳米医学目前被开发用于制造治疗性DDS和治疗各种疾病和疾病的方案。为了获得DDS,我们使用了不同类型的材料。从有机到无机,从极性到非极性,从微观到纳米材料,从0D到三维结构材料。其中许多材料在文献中得到了广泛的研究和评述。 目的:本综述的目的是对药物释放系统进行明确的概述,这些系统取决于几个方面,包括药物的传递机制、载体的类型、药物的活性。在预防或治疗各种疾病中的潜在应用。 结果:根据0、1、2和三维给药系统的性质和应用,对其合成问题、特点及潜在用途进行了广泛的讨论。这些系统ms可以根据给药机制(0-3d递送)和使用更多的活性药物来定制,具有更多的治疗活性或相同的活性,但具有不同的机制。艾尔。药物传递系统的大小和形态是必不可少的,尤其是当谈到肿瘤细胞的内化时,而移动性则特别依赖于肿瘤细胞的大小。近几十年来,人们对载体的性质及其极性的影响以及孔隙度和孔径的重要性进行了广泛的研究,但论文的研究还很有限。从整体上分析了载体的尺寸和传递活性物质的方法。 结论:本综述是从一个新的、研究较少的角度对药物释放系统进行全面的洞察,这意味着给药系统的维度。分娩的特点。
关键词: 纳米技术,纳米粒子,0-3D材料,药物传递,纳米医学,上层建筑。
图形摘要
Current Drug Targets
Title:Advances in Drug Delivery Systems, from 0 to 3D superstructures
Volume: 19 Issue: 4
关键词: 纳米技术,纳米粒子,0-3D材料,药物传递,纳米医学,上层建筑。
摘要: Background: Nanomedicine is currently exploited for manufacturing therapeutic DDS and treatments protocols for various diseases and disorders. To obtain DDS, different types of materials are used, from organic to inorganic, polar to non-polar, micro to nanomaterials from 0D to 3D structured materials, respectively. Many of these materials were extensively studied and reviewed in the literature.
Objective: The objectives of this review is to make a clear overview on drug delivery systems depending several aspects related to delivery mechanisms, the type of supports, the active agents ant the potential applications in the prevention or treatment of various diseases.
Results: Following aspects are extensively debated: synthesis issues, characteristics and potential uses of 0, 1, 2 and 3D drug delivery systems according to their nature and applications. These systems can be can be tailored according to the delivery mechanism (0-3D delivery) as well as by using more active agents, with more therapeutic activity or same activity but with different mechanisms of action. The size and morphology of the drug delivery system is essential, especially when talking about the internalization into the tumor cells while the mobility is especially dependent on the size. The influence of the nature of the supports and their polarity was extensively studied during the last decades, as well as the importance of the porosity and pore size, but only limited papers are devoted to the holistic analysis of the dimensionality of the support and the ways of delivering the active agents.
Conclusion: This review is devoted to a holistic insight into the drug delivery systems, from a new, only marginally studied point of view, meaning the dimensionality of the drug delivery systems and the characteristics of the delivery.
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Cite this article as:
Advances in Drug Delivery Systems, from 0 to 3D superstructures, Current Drug Targets 2018; 19 (4) . https://dx.doi.org/10.2174/1389450117666160401122926
DOI https://dx.doi.org/10.2174/1389450117666160401122926 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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