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Current HIV Research

Editor-in-Chief

ISSN (Print): 1570-162X
ISSN (Online): 1873-4251

Review Article

Mechanisms of Blood-Retinal Barrier Disruption by HIV-1

Author(s): Yiwen Qian, Xin Che, Jing Jiang and Zhiliang Wang*

Volume 17, Issue 1, 2019

Page: [26 - 32] Pages: 7

DOI: 10.2174/1570162X17666190315163514

Price: $65

Abstract

It has been found that human immunodeficiency virus (HIV)-1 RNA or antigens can be detected in the intraocular tissues of HIV-1 patients even under effective highly active anti-retroviral therapy (HAART). In vivo, blood-retinal barrier (BRB) establishes a critical, physiological guardian against microbial invasion of the eye, but may be compromised in the presence of HIV-1. The envelope glycoprotein gp120 is exposed on the surface of the HIV envelope, essential for virus entry into cells by the attachment to specific cell surface receptors. The BRB disruption by glycoprotein gp120 has been widely recognized, which is toxic to human retinal epithelial cells (RPE) and umbilical vein endothelial cells (HUVEC). The present review elaborates on various mechanisms of BRB disruption induced by HIV gp120, which may represent potential targets for the prevention of ocular HIV complications in the future.

Keywords: Blood-retinal barrier, HIV gp120, tight junction proteins, inflammatory cytokines, oxidative stress, MMPs.

Graphical Abstract

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