Abstract
Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.
Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors
Current Genomics
Title: Genetic Abnormalities in Prostate Cancer
Volume: 5 Issue: 1
Author(s): Sanjeev Shukla, Gregory T. MacLennan, Susan R. Marengo, Allen D. Seftel, Martin I. Resnick and Sanjay Gupta
Affiliation:
Keywords: prostate cancer, genetic abnormality, tumor suppressor genes, oncogenes, inheritable genes, metastasis, apoptosis, transcription factors
Abstract: Molecular genetic mechanisms show diversity during prostate carcinogenesis due to extensive tumor heterogeneity and gene complexity. Understanding the molecular mechanisms involved in initiation and progression of prostate cancer will lead to the development of strategies for early detection, prevention and therapeutic intervention. This review focuses on inheritable and sporadic prostate cancer genes involved in proliferation, metastasis, angiogenesis, tumor suppression, apoptosis, and cellular stress responses.
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Cite this article as:
Shukla Sanjeev, MacLennan T. Gregory, Marengo R. Susan, Seftel D. Allen, Resnick I. Martin and Gupta Sanjay, Genetic Abnormalities in Prostate Cancer, Current Genomics 2004; 5 (1) . https://dx.doi.org/10.2174/1389202043490014
DOI https://dx.doi.org/10.2174/1389202043490014 |
Print ISSN 1389-2029 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5488 |
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