摘要
肿瘤学主要的药物发现都集中在选择性分子的发展中,他们被认为在这种通过修饰一个单一的或几个密切相关的药物靶点的抗肿瘤机制中有特异的行为。然而,鸟瞰多个可用的生物数据到大部分批准的抗癌药物中,事实上,目标更多的药物具有不同的功能。在这里我们将回顾当代可用的信息在不同抗癌药物和他们潜在的活性机制的靶点。目前抗肿瘤药物的多向药理学表明肿瘤药物临床疗效只能通过多个细胞机制调制实现。
关键词: 多向药理学,酪氨酸激酶抑制剂,组蛋白去乙酰化酶抑制剂,DNA拓扑异构酶抑制剂、他莫昔芬、药物靶点,多靶点药物的合理设计。
图形摘要
Current Drug Targets
Title:Polypharmacology of Approved Anticancer Drugs
Volume: 18 Issue: 5
关键词: 多向药理学,酪氨酸激酶抑制剂,组蛋白去乙酰化酶抑制剂,DNA拓扑异构酶抑制剂、他莫昔芬、药物靶点,多靶点药物的合理设计。
摘要: The major drug discovery efforts in oncology have been concentrated on the development of selective molecules that are supposed to act specifically on one anticancer mechanism by modulating a single or several closely related drug targets. However, a bird's eye view on data from multiple available bioassays implies that most approved anticancer agents do, in fact, target many more proteins with different functions. Here we will review and systematize currently available information on the targets of several anticancer drugs along with revision of their potential mechanisms of action. Polypharmacology of the current antineoplastic agents suggests that drug clinical efficacy in oncology can be achieved only via modulation of multiple cellular mechanisms.
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Cite this article as:
Polypharmacology of Approved Anticancer Drugs, Current Drug Targets 2017; 18 (5) . https://dx.doi.org/10.2174/1389450117666160301095233
DOI https://dx.doi.org/10.2174/1389450117666160301095233 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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