摘要
“西方社会”的生活方式,是基于过度消耗高能量饮食和身体活动。这种行为对生物系统的代谢性疾病的发展有压力。这代谢性疾病的发病率的增加也伴随着男性生殖健康的下降,特别是在年轻男性中间。男性的生育能力对代谢功能障碍是敏感的,如糖尿病,其破坏能量代谢和繁殖之间的联系。证据表明,糖尿病引起的损害精子参数与受损的睾丸代谢相关,表明缺乏睾丸生物能有助于减少精子发生。能量代谢是一个协调一致的过程,涉及一个碳水化合物网络,脂质和蛋白质的代谢途径。这个复杂的过程是线粒体和细胞核之间的平衡行为,由代谢传感器统治,如样蛋白。样蛋白在代谢控制的新兴角色已经凸显,特别是在肿瘤代谢。对表现出一种“似瓦尔堡代谢”的作用的非癌细胞却鲜有关注,如睾丸支持细胞。因为睾丸支持细胞产生的乳酸是生殖细胞的主要底物,所以精子发生是高度依赖于糖酵解代谢。在糖酵解代谢下的样蛋白调控不仅增加他们与睾丸环境相关的生理,而且也表明,这些蛋白质可以控制男性生育能力。本文将讨论在最近的研究结果中样蛋白在睾丸新陈代谢的作用,并将提出可以样蛋白可作为抵消由糖尿病引起的不孕/不育的一个潜在靶点的概念。
关键词: 糖尿病,男性生育力,睾丸新陈代谢样蛋白,精子发生,精子。
Current Medicinal Chemistry
Title:Sirtuins: Novel Players in Male Reproductive Health
Volume: 23 Issue: 11
Author(s): Luís Rato, Marco G. Alves, Branca M. Silva, Mário Sousa, Pedro F. Oliveira
Affiliation:
关键词: 糖尿病,男性生育力,睾丸新陈代谢样蛋白,精子发生,精子。
摘要: The current lifestyle of “western societies” is based on excessive consumption of high-energy diets and physical inactivity. Such behavior has pressured biological systems towards the development of metabolic diseases. This increased incidence of metabolic disorders is also accompanied by a decline in male reproductive health, particularly among young males. Male fertility is sensitive to metabolic dysfunctions, such as diabetes mellitus, which disrupt the link between energy metabolism and reproduction. Evidences showed that compromised sperm parameters induced by diabetes are associated with impaired testicular metabolism, suggesting that deficient testicular bioenergetics contributes to a decline in spermatogenesis. Energy metabolism is a well-coordinated process that involves a network of carbohydrate, lipid and protein metabolic pathways. This intricate process is an act of balance between mitochondria and nucleus, governed by metabolic sensors, such as sirtuins. The emerging role of sirtuins in the control of metabolism has been highlighted, specially in cancer metabolism. Little attention has been given to their role in non-cancerous cells that exhibit a “Warburg-like metabolism”, such as Sertoli cells. Spermatogenesis is highly dependent on glycolytic metabolism, since the lactate produced by Sertoli cells is the major substrate of germ cells. The regulation of sirtuins in the glycolytic metabolism not only increases their physiological relevance to the testicular environment, but also suggests that these proteins may control male fertility. This review will discuss the recent findings in the role of sirtuins in testicular metabolism and will address the concept that sirtuins can be a potential target to counteract subfertility/infertility promoted by diabetes mellitus.
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Luís Rato, Marco G. Alves, Branca M. Silva, Mário Sousa, Pedro F. Oliveira , Sirtuins: Novel Players in Male Reproductive Health, Current Medicinal Chemistry 2016; 23 (11) . https://dx.doi.org/10.2174/0929867323666160229114248
DOI https://dx.doi.org/10.2174/0929867323666160229114248 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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