摘要
β淀粉样蛋白(Aβ)被认为是阿尔茨海默病的一个主要特征。越来越多的证据证明β淀粉样蛋白小的水溶性低聚物是这种肽能引发AD的有毒形态。不同的因素(包括β淀粉样蛋白分子内的一些主要残基,细胞膜,朊蛋白和金属)在诱发AD中起重要作用。关于了解这些因素和解决β淀粉样蛋白的细胞毒性机制,科学家们已经有了重大发现。这篇综述总结了当前在β淀粉样蛋白和AD研究领域的发现,这些知识能使药物化学家设计和发展AD的治疗法。
关键词: β淀粉样蛋白肽,阿尔茨海默症,低聚物,细胞毒性,朊蛋白,金属相互作用。
Current Medicinal Chemistry
Title:Amyloid Beta (Aβ) Peptide and Factors that Play Important Roles in Alzheimer’s Disease
Volume: 23 Issue: 9
Author(s): Elaheh Jamasbi, John D. Wade, Frances Separovic, Mohammed A. Hossain
Affiliation:
关键词: β淀粉样蛋白肽,阿尔茨海默症,低聚物,细胞毒性,朊蛋白,金属相互作用。
摘要: Amyloid beta peptide (Aβ) is recognised as a main feature of Alzheimer’s disease (AD). Increasing evidence suggests that small soluble oligomers of Aβ are the toxic form of the peptide and may instigate AD. Different factors including some key residues within Aβ molecule, the cell membrane, prion protein and metals play important roles in developing AD. Significant progress has been made to understand these factors and elucidate the mechanism of cytotoxicity of Aβ. This review summarizes recent findings in the area of Aβ and AD research, and this current knowledge could enable medicinal chemists to design and develop therapeutics to treat AD.
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Elaheh Jamasbi, John D. Wade, Frances Separovic, Mohammed A. Hossain , Amyloid Beta (Aβ) Peptide and Factors that Play Important Roles in Alzheimer’s Disease, Current Medicinal Chemistry 2016; 23 (9) . https://dx.doi.org/10.2174/0929867323666160229113911
DOI https://dx.doi.org/10.2174/0929867323666160229113911 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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