Experimental Models for Evaluation of Nanoparticles in Cancer Therapy

Title:Experimental Models for Evaluation of Nanoparticles in Cancer Therapy

Volume: 17 Issue: 18

Author(s): Prashant Kesharwani*, Raksha Ghanghoria and Narendra K. Jain

Affiliation:

• Department of Pharmaceutical Sciences, Eugene Applebaum College of Pharmacy and Health Sciences, Wayne State University, Detroit, MI (48201),United States

Keywords: Cancer, cell lines studies, chemotherapy, cytotoxicity, ex vivo studies, nanoparticles.

Abstract: Nanoparticles (NPs), the submicron-sized colloidal particles, have recently generated enormous interest among biomedical scientists, particularly in cancer therapy. A number of models are being used for exploring NPs safety and efficacy. Recently, cancer cell lines have explored as prominent experimental models for evaluating pharmacokinetic parameters, cell viability, cytotoxicity and drug efficacy in tumor cells. This review aims at thorough compilation of various cancer cell lines and in vivo models for evaluation of efficacy of NPs on one platform. This will provide a basis to explore and improvise pre-clinical models as a prelude to successful cancer research.

Cite this article as:

Kesharwani Prashant*, Ghanghoria Raksha and Jain K. Narendra, Experimental Models for Evaluation of Nanoparticles in Cancer Therapy, Mini-Reviews in Medicinal Chemistry 2017; 17 (18) . https://dx.doi.org/10.2174/1389557516666160219122233