摘要
锂与对免疫功能的各种影响有关联,如今仍然是知之甚少。许多细胞因子对多种神经发育过程起特征性的作用,包括神经再生、神经元和神经胶质细胞的迁移、增殖、分化、突触的成熟和突触的剪切。本项工作的目的是评估不同剂量(0.02;0.2和2mM)的锂对皮质和海马神经元与胶质细胞共培养的细胞因子分泌的影响。我们的研究结果表明,低剂量氯化锂的长期治疗能够改变在皮质和海马神经元与胶质细胞共培养的炎前和抗炎白细胞介素的分泌。
关键词: 共培养,皮层神经元,海马神经元,锂,神经保护作用,炎前和抗炎的白细胞介素。
Current Alzheimer Research
Title:Lithium Distinctly Modulates the Secretion of Pro- and Anti- Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations
Volume: 13 Issue: 8
Author(s): Vanessa J. De-Paula, Daniel S. Kerr, Gustavo Scola, Wagner F. Gattaz, Orestes V. Forlenza
Affiliation:
关键词: 共培养,皮层神经元,海马神经元,锂,神经保护作用,炎前和抗炎的白细胞介素。
摘要: Lithium is associated with various effects on immune functions, some of which are still poorly understood. The roles of many cytokines have been characterized in a variety of neurodevelopmental processes including neurogenesis, neuronal and glial cell migration, proliferation, differentiation, synaptic maturation and synaptic pruning. This work aims to evaluate the effects of different doses of lithium (0.02; 0.2 and 2mM) on the secretion of cytokines in co-cultures of cortical and hippocampal neurons with glial cells. Our results indicate that chronic treatment with lithium chloride at subtherapeutic concentrations are able to modify the secretion of pro- and anti-inflammatory interleukins in co-cultures of cortical and hippocampal neurons with glial cells.
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Vanessa J. De-Paula, Daniel S. Kerr, Gustavo Scola, Wagner F. Gattaz, Orestes V. Forlenza , Lithium Distinctly Modulates the Secretion of Pro- and Anti- Inflammatory Interleukins in Co-Cultures of Neurons and Glial Cells at Therapeutic and Sub-Therapeutic Concentrations, Current Alzheimer Research 2016; 13 (8) . https://dx.doi.org/10.2174/1567205013666160219112612
DOI https://dx.doi.org/10.2174/1567205013666160219112612 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
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Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
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