摘要
背景:在这个工业化的世界,15%的夫妻遭受了不孕不育的问题。与此相应,任何可能由治疗不孕不育症导致的潜在终身患病率引起了对公众健康的极大关注。不孕不育药物的作用,虽然主要是有关于他们通过对经典的调控荷尔蒙的靶组织(包括性轴,即子宫,卵巢和乳房)的可能影响(掩盖一些再生产荷尔蒙的受体),但是也可能对其他的器官有影响。当对一个人的不孕不育治疗影响到达恶性肿瘤出现的条件时,毫无疑问的是肿瘤在那些遭受不孕不育或者正在治疗不育不孕的女性身上,倾向于频繁复发。 目的:综述关于治疗经典性固醇类靶器官和非靶器官的恶性肿瘤性不孕的累积数据。 方法:系统汇编相关文献。 结果与讨论:与大家普遍认知相反,不孕不育的治疗与恶性肿瘤的增长几乎无关。
关键词: 不孕不育,恶性肿瘤,促性腺激素,克罗米芬,流行病学,恶性肿瘤的风险
Current Medicinal Chemistry
Title:The Possible Role of Infertility Drugs in Later Malignancy: A Review
Volume: 23 Issue: 9
Author(s): Moshe Schaffer, Pamela Manuela Schaffer, Riad Kassem, Izhar Ben Shlomo
Affiliation:
关键词: 不孕不育,恶性肿瘤,促性腺激素,克罗米芬,流行病学,恶性肿瘤的风险
摘要: Background: Some 15% of all couples in the industrialized world suffer from infertility. Accordingly, any possible life-long morbidity that may result from treatments for infertility presents a significant concern to public health. The use of medications for infertility is specifically relevant to their possible effects on the classical target tissues for hormones involved in the sex axes, i.e., uterus, ovaries, and breast, but may have an effect on other organs, which harbor receptors for some of the hormones involved in reproduction. When one deals with the effect of treatment for infertility on the occurrence of malignant conditions, there is no doubt that certain malignancies tend to occur more frequently in women who suffered from and/or were treated for infertility. Objective: To review the accumulated data on the association of treatments for infertility with subsequent malignancies both in the classical target organs of sex steroids and in non-target organs. Methods: Systematic compilation of the relevant literature. Results & Conclusion: Contrary to popular believes, treatment for infertility is associated with very little increase in malignacies.
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Cite this article as:
Moshe Schaffer, Pamela Manuela Schaffer, Riad Kassem, Izhar Ben Shlomo , The Possible Role of Infertility Drugs in Later Malignancy: A Review, Current Medicinal Chemistry 2016; 23 (9) . https://dx.doi.org/10.2174/0929867323666160217123443
DOI https://dx.doi.org/10.2174/0929867323666160217123443 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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