Abstract
In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5’Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.
Keywords: AMPK, anti-cancer, diabetes, natural, synthetic.
Anti-Cancer Agents in Medicinal Chemistry
Title:5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents
Volume: 16 Issue: 8
Author(s): Abhishek Thakur, Nirnoy Dan, Soumendranath Bhakat, Venkatesan Jayaprakash and Sugato Banerjee
Affiliation:
Keywords: AMPK, anti-cancer, diabetes, natural, synthetic.
Abstract: In spite of tremendous advancement in the field of cancer therapy, it is still one of the leading causes of death worldwide. One of the newest targets in the field of cancer therapeutics is 5’Adenosine Mono Phosphate activated protein kinase (AMPK). In vitro and in vivo evidences suggest anti-cancer activity of AMPK. AMPK activation may promote catabolism while preventing the anabolic processes of cell. Thus it may modulate cellular protein and lipid metabolism and affect the growth and division of cell. Here we review the mechanisms of action of AMPK modulators as future anti-cancer agents.
Export Options
About this article
Cite this article as:
Thakur Abhishek, Dan Nirnoy, Bhakat Soumendranath, Jayaprakash Venkatesan and Banerjee Sugato, 5' Adenosine Monophosphate-Activated Protein Kinase Modulators as Anticancer Agents, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (8) . https://dx.doi.org/10.2174/1871520616666160211124240
DOI https://dx.doi.org/10.2174/1871520616666160211124240 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Detecting Personalized Determinants During Drug Treatment from Omics Big Data
Current Pharmaceutical Design Steroids and the Endometrium
Current Medicinal Chemistry Ligand Binding Domain of Vitamin D Receptors
Current Topics in Medicinal Chemistry Nanomedicine: Magnetic Nanoparticles and their Biomedical Applications
Current Medicinal Chemistry Major Developments in the Design of Inhibitors along the Kynurenine Pathway
Current Medicinal Chemistry Purine and Pyrimidine Pathways as Targets in Plasmodium falciparum
Current Topics in Medicinal Chemistry Metalloproteinases Suppression Driven by the Curcumin Analog DM-1 Modulates Invasion in BRAF-Resistant Melanomas
Anti-Cancer Agents in Medicinal Chemistry A New Class of Pure Estrogen Alpha Receptor Antagonists; Design, Synthesis and in-vitro Screening
Letters in Drug Design & Discovery Efficacy of High-Dose Vitamin D Supplementation in the Critically Ill Patients
Inflammation & Allergy - Drug Targets (Discontinued) Synthetic Lethal Interactions in Cancer Therapy
Current Cancer Drug Targets The Role of Fibroblast Growth Factors in Tumor Growth
Current Cancer Drug Targets Examining the Relationship between Cancer Invasion / Metastasis and Drug Resistance
Current Cancer Drug Targets The Therapeutic Potential of Small Activating RNAs for Colorectal Carcinoma
Current Gene Therapy Polysaccharide-Based Nanobiomaterials as Controlled Release Systems for Tissue Engineering Applications
Current Pharmaceutical Design Preface: A New Era of Nanoimmunology
Current Pharmaceutical Biotechnology Fluorescence Imaging in Cancerology
Current Molecular Imaging (Discontinued) Anti-inflammatory Treatment of Acute Coronary Syndromes
Current Pharmaceutical Design A Review on the Sex Differences in Organ and System Pathology with Alcohol Drinking
Current Drug Abuse Reviews Editorial [Hot Topic: Tumor Immunology (Guest Editors: Bharat H. Joshi and Raj K. Puri)]
Current Molecular Medicine Gene Therapy in the Transplantation of Allogeneic Organs and Stem Cells
Current Gene Therapy