刺激反应灵敏的脂质体在癌症靶向中的应用

Title:Stimuli-responsive Smart Liposomes in Cancer Targeting

Volume: 19 Issue: 3

关键词: 刺激敏感，脂质体，热敏感，pH敏感，超声波敏感，智能输送。

摘要: Background: Liposomes are vesicular carriers which possess aqueous core entrapped within the lipid bilayer. These are carriers of choice because of biocompatible and biodegradable features in addition to flexibility of surface modifications at surface and lipid compositions of lipid bilayers.

Objective: Liposomes have been reported well for cancer treatment using both passive and active targeting approaches however tumor microenvironment is still the biggest hurdle for safe and effective delivery of anticancer agents. To overcome this problem, stimuli-responsive smart liposomes have emerged as promising cargoes pioneered to anomalous tumor milieu in response to pH, temperature, and enzymes etc. as internal triggers, and magnetic field, ultrasound, and redox potential as external guides for enhancement of drug delivery to tumors.

Conclusion: This review focuses on all such stimuli-responsive approaches using fabrication potentiality of liposomes in combination to various ligands, linkers, and PEGylation etc. Scientists engaged in cancer targeting approaches can get benefited greatly with this knowledgeable assemblage of advances in liposomal nanovectors.

Cite this article as:

Stimuli-responsive Smart Liposomes in Cancer Targeting, Current Drug Targets 2018; 19 (3) . https://dx.doi.org/10.2174/1389450117666160208144143