神经退行性疾病中的AMPK：意义和治疗的角度

Title:AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives

Volume: 17 Issue: 8

Author(s): Claudia Marinangeli, Sébastien Didier, Valérie Vingtdeux

Affiliation:

关键词: AMPK、阿尔茨海默病、帕金森病、Huntington病、肌萎缩性侧索硬化、缺血性中风、神经退行性疾病，神经发育。

摘要: Maintaining proper energy levels in brain neurons is crucial for many cerebral functions such as synaptic transmission, vesicle recycling and axonal transport. AMP-activated protein kinase (AMPK) is the main energy sensor of all living cells. Beside its role as a crucial whole-body energy sensor in hypothalamic neurons, AMPK is also expressed in neurons throughout the brain where it might play additional fundamental roles. For instance, AMPK might be involved in brain development, neuronal polarization and neuronal activity. In addition, recent evidences suggest that AMPK deregulation might participate in neurodegenerative diseases such as Alzheimer’s, Parkinson’s, Huntington’s, amyotrophic lateral sclerosis and ischemic stroke. Therefore, AMPK is emerging as a potential therapeutic target for these neurodegenerative diseases. Here, we will review the recent literature regarding the physiological and pathological role of AMPK in the brain and discuss the resulting potential therapeutic implications.

Cite this article as:

Claudia Marinangeli, Sébastien Didier, Valérie Vingtdeux , AMPK in Neurodegenerative Diseases: Implications and Therapeutic Perspectives, Current Drug Targets 2016; 17 (8) . https://dx.doi.org/10.2174/1389450117666160201105645