Abstract
Prostate cancer is the most common cancer among American men and the second most common cause of cancer deaths among men. Treatment of prostate cancer remains a challenge. Despite decades of research, few cytotoxic chemotherapy agents have shown promise against prostate cancer. In this paper, we will discuss the history of chemotherapy in prostate cancer, the pivotal trials with docetaxel that advanced the field, the cytotoxic chemotherapy agents, including cabazitaxel, as well as combination therapy with docetaxel or cabazitaxel and the potential implications of biomarkers such as AR-V7 in chemotherapy use.
Keywords: Chemotherapy, prostate cancer, docetaxel, cabazitaxel.
Graphical Abstract
Anti-Cancer Agents in Medicinal Chemistry
Title:The Utility of Chemotherapy in the Treatment of Metastatic Prostate Cancer
Volume: 16 Issue: 9
Author(s): Kanika Gupta, Jacob Elkon, Ehab El-Bahesh and Jeanny B. Aragon-Ching
Affiliation:
Keywords: Chemotherapy, prostate cancer, docetaxel, cabazitaxel.
Abstract: Prostate cancer is the most common cancer among American men and the second most common cause of cancer deaths among men. Treatment of prostate cancer remains a challenge. Despite decades of research, few cytotoxic chemotherapy agents have shown promise against prostate cancer. In this paper, we will discuss the history of chemotherapy in prostate cancer, the pivotal trials with docetaxel that advanced the field, the cytotoxic chemotherapy agents, including cabazitaxel, as well as combination therapy with docetaxel or cabazitaxel and the potential implications of biomarkers such as AR-V7 in chemotherapy use.
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Cite this article as:
Gupta Kanika, Elkon Jacob, El-Bahesh Ehab and Aragon-Ching B. Jeanny, The Utility of Chemotherapy in the Treatment of Metastatic Prostate Cancer, Anti-Cancer Agents in Medicinal Chemistry 2016; 16 (9) . https://dx.doi.org/10.2174/1871520616666160121113558
DOI https://dx.doi.org/10.2174/1871520616666160121113558 |
Print ISSN 1871-5206 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5992 |
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