摘要
本文主要关注于术中处理和自体细胞特别是心房来源细胞(AADCs)和微小细胞分离的可能性,以及细胞移植治疗心衰的简单应用。我们讨论了自体组织作为细胞治疗来源的潜力并考虑到这些用于手术治疗的组织的多馀的部分目前被认为是手术废物在作为基因和RNA治疗途径的成本功效和可用性方面,我们对培养扩增的细胞和新鲜分离的该细胞进行了对比。我们也对金融认证权限是如何为病人参加学术基础实验创造条件的进行了总结。最后,我们提供了一个冠状动脉搭桥术过程中用于心外膜起搏治疗的AADCs分离和处理的实例。
关键词: 自体细胞移植,基因治疗,RNA疗法,最小细胞操作,心肌微小细胞。
Current Gene Therapy
Title:Rational Autologous Cell Sources For Therapy of Heart Failure - Vehicles and Targets For Gene and RNA Therapies
Volume: 16 Issue: 1
Author(s): Milla Lampinen, Antti Vento, Jari Laurikka, Johanna Nystedt, Eero Mervaala, Ari Harjula and Esko Kankuri
Affiliation:
关键词: 自体细胞移植,基因治疗,RNA疗法,最小细胞操作,心肌微小细胞。
摘要: This review focuses on the possibilities for intraoperative processing and isolation of autologous cells, particularly atrial appendage-derived cells (AADCs) and cellular micrografts, and their straightforward use in cell transplantation for heart failure therapy. We review the potential of autologous tissues to serve as sources for cell therapy and consider especially those tissues that are used in surgery but from which the excess is currently discarded as surgical waste. We compare the inculture expanded cells to the freshly isolated ones in terms of evidence-based cost-efficacy and their usability as gene- and RNA therapy vehicles. We also review how financial and authority-based decisions and restrictions sculpt the landscape for patients to participate in academic-based trials. Finally, we provide an insight example into AADCs isolation and processing for epicardial therapy during coronary artery bypass surgery.
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Milla Lampinen, Antti Vento, Jari Laurikka, Johanna Nystedt, Eero Mervaala, Ari Harjula and Esko Kankuri , Rational Autologous Cell Sources For Therapy of Heart Failure - Vehicles and Targets For Gene and RNA Therapies, Current Gene Therapy 2016; 16 (1) . https://dx.doi.org/10.2174/1566523216666160104141809
DOI https://dx.doi.org/10.2174/1566523216666160104141809 |
Print ISSN 1566-5232 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5631 |
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