姜黄素对癌症的两亲性聚合物胶束的设计研究

Title:The Design of Amphiphilic Polymeric Micelles of Curcumin for Cancer Management

Volume: 22 Issue: 38

Author(s): M. Liu, H. Du and Guangxi Zhai

Affiliation:

关键词: 姜黄素，聚合物胶束（PMMCs），两亲聚合物、内部刺激的反应，药物传递，癌症治疗。

摘要: Curcumin, a natural phenolic compound mainly extracted from turmeric curcuma longa, has been employed to prevent or treat plenty of diseases particularly cancer. It has been proven to modulate various signal transduction pathways and exhibits antiinflammatory, anti-oxidative, anti-metastasis anti-proliferative, anti-angiogenic in addition anti-cancer activities. However, its poor solubility and rapid degradation severely hampers the introduction into clinical setting. In this review, we focus on the design of polymeric micelles (PMMCs) which are nano-scaled drug delivery vehicles and fabricated from biocompatible polymers for efficient curcumin delivery. In particular, recent progress of curcumin loaded internal stimuli responsive PMMCs for further intracellular uptake via internal triggers is also discussed.

Cite this article as:

M. Liu, H. Du and Guangxi Zhai , The Design of Amphiphilic Polymeric Micelles of Curcumin for Cancer Management, Current Medicinal Chemistry 2015; 22 (38) . https://dx.doi.org/10.2174/092986732238151228191020