摘要
新兴的免疫治疗靶向检查点和肿瘤相关抗原引导了重要的临床进展以及提供给患有前列腺癌(PCa),膀胱癌(BC),特别是肾细胞癌(RCC)的患者一种新武器。在当前的治疗方案或泌尿生殖肿瘤中,以排序或组合的方法来整合这些因子,这取决于对免疫系统以及癌症相关的免疫抑制机制促癌活性的更为深刻的理解。在这方面,中性粒细胞,T、B淋巴细胞以及肿瘤相关的巨噬细胞(TAMs)与发病机制,泌尿系统肿瘤耐药性的发生和发展有牵连。这篇文章是一个关于免疫细胞作用最新见解的综述。
关键词: 泌尿生殖系统肿瘤;免疫治疗;淋巴细胞;巨噬细胞;中性粒细胞。
图形摘要
Current Drug Targets
Title:An Overview of Emerging Immunotargets of Genitourinary Tumors
Volume: 17 Issue: 7
Author(s): Rodolfo Montironi, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Marc R. Matrana, Holger Moch and Marina Scarpelli
Affiliation:
关键词: 泌尿生殖系统肿瘤;免疫治疗;淋巴细胞;巨噬细胞;中性粒细胞。
摘要: Emerging immunotherapies targeting immune checkpoints and tumor associated antigens are leading to important clinical advances and providing a new weapon in patients with prostate (PCa) and bladder cancer (BC) and, in particular, with renal cell carcinoma (RCC). The possibility to integrate these agents in the current therapeutic scenario or genitourinary tumors, both in sequential or combined approaches, relies on a more profound comprehension of the protumorigenic activity of the immune system and of the mechanisms of cancer-related immunosuppression. In this regards, neutrophils, T and B lymphocytes and tumor-associated macrophages (TAMs) are implicated in the pathogenesis, progression and development of drug resistance in genitourinary tumors. This review is an overview on the recent insights concerning the role of immune cells in this context.
Export Options
About this article
Cite this article as:
Rodolfo Montironi, Matteo Santoni, Liang Cheng, Antonio Lopez-Beltran, Francesco Massari, Marc R. Matrana, Holger Moch and Marina Scarpelli , An Overview of Emerging Immunotargets of Genitourinary Tumors, Current Drug Targets 2016; 17 (7) . https://dx.doi.org/10.2174/1389450117666151209144649
DOI https://dx.doi.org/10.2174/1389450117666151209144649 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
Related Journals
Related Books
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
Related Articles
-
Deubiquitinating Enzymes as Therapeutic Targets in Cancer
Current Pharmaceutical Design Harnessing the Potential of Long Non-coding RNAs to Manage Metabolic Diseases
Current Pharmaceutical Design A Molecular Link Between Diabetes and Breast Cancer: Therapeutic Potential of Repurposing Incretin-based Therapies for Breast Cancer
Current Cancer Drug Targets Alternative Splicing: A Promising Target for Pharmaceutical Inhibition of Pathological Angiogenesis?
Current Pharmaceutical Design ErbB Targeted Drugs and Angiogenesis
Current Vascular Pharmacology Molecular Foundations for Personalized Therapy in Prostate Cancer
Current Drug Targets High Expression of MYL9 Indicates Poor Clinical Prognosis of Epithelial Ovarian Cancer
Recent Patents on Anti-Cancer Drug Discovery Organosulfur Compounds in Cancer Chemoprevention
Mini-Reviews in Medicinal Chemistry Anti-cancer and Other Bioactivities of Korean Angelica gigas Nakai (AGN) and Its Major Pyranocoumarin Compounds
Anti-Cancer Agents in Medicinal Chemistry Anticancer Activity of New Haloalkyl Camptothecin Esters against Human Cancer Cell Lines and Human Tumor Xenografts Grown in Nude Mice
Anti-Cancer Agents in Medicinal Chemistry Exploring the Potential of NO-Independent Stimulators and Activators of Soluble Guanylate Cyclase for the Medical Treatment of Erectile Dysfunction
Current Pharmaceutical Design Natural Compounds as Anticancer Agents Targeting DNA Topoisomerases
Current Genomics The Endothelin Axis as Therapeutic Target in Human Malignancies: Present and Future
Current Pharmaceutical Design D Allele Frequency in Insertion/Deletion Polymorphism of the Angiotensin Converting Enzyme (ACE) Gene is Associated with Development of Breast Cancer Risk in Indian Women
Current Proteomics Regulating miRNA by Natural Agents as a New Strategy for Cancer Treatment
Current Drug Targets Nano-Enabled Drug Delivery in Cancer Therapy: Literature Analysis Using the MeSH System
Pharmaceutical Nanotechnology Substance P: Structure, Function, and Therapeutics
Current Topics in Medicinal Chemistry Cancer Therapy: Targeting Cell Cycle Regulators
Anti-Cancer Agents in Medicinal Chemistry Role of Mitochondrial Heat-shock Proteins and Immunophilins in Neuro Degenerative Diseases
Current Drug Targets Inhibition of EGFR Signaling by N-cyclohexyl-2-(1-(phenylsulfonyl)piperidin-4-yl) acetamide
Anti-Cancer Agents in Medicinal Chemistry