摘要
在最近的几十年中,人们对整合素受体在癌症生物学特别是在前列腺肿瘤的发展中的应用越来越感兴趣。有报道称整合素能调控多种机制,如细胞的存活、增殖、分化和迁移。本文报道了整合素信号机制在转移性前列腺肿瘤发展、肿瘤生长原发灶和转移灶之间的信号联系、肿瘤细胞和组织微环境之间的相互作用和上皮间质转化(EMT)中的作用。最后,本文讨论了以整合素为基础的化疗药物在临床上的作用,并对以整合素为靶点作为癌症药物提出了深刻的见解。
关键词: 拮抗剂治疗,整合素,前列腺癌。
Current Drug Targets
Title:Therapeutic Value of an Integrin Antagonist in Prostate Cancer
Volume: 17 Issue: 3
Author(s): Clement-Lacroix Philippe
Affiliation:
关键词: 拮抗剂治疗,整合素,前列腺癌。
摘要: In recent decades we have seen an exponential interest in the implications of integrin receptors in cancer biology and especially in prostate tumour development. Integrins has been reported to control multiple mechanisms, such as cell survival, proliferation, differentiation, and migration. Here, we report the current understanding of the integrin signalling mechanisms in metastatic prostate tumour development, cross-talks between the primary and metastatic sites on tumour growth, interactions between tumour cells and tissue microenvironment, and epithelial-mesenchymal transition (EMT). Finally, this review presents the integrin-based chemotherapeutic agents currently under clinically consideration and provides an insight into cancer drug development using integrin as a target.
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Cite this article as:
Clement-Lacroix Philippe , Therapeutic Value of an Integrin Antagonist in Prostate Cancer, Current Drug Targets 2016; 17 (3) . https://dx.doi.org/10.2174/1389450117666151209115324
DOI https://dx.doi.org/10.2174/1389450117666151209115324 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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