Abstract
The developing number of hepatitis C virus infected cases worldwide has threatened people’s health. The available therapeutic options have low specificity, side effects and high rate of drug resistance and thus potentiate the need for novel effective anti-HCV drugs. Agents obtained from natural sources offer an enormous scope of structural diversity and broad therapeutic range of coverage. This review summarizes the research and development of anti-HCV agents (plant extracts/isolated components) obtained from various natural sources along with the associated mechanism of HCV inhibition. Some of the reported examples include triterpenes, naringenin, Proanthocyanidin, curcumin, Epigallocatechin-3-gallate, quercetin and abrogates having diverse anti-HCV properties. The compiled knowledge regarding anti-HCV agents from natural sources will provide considerable information for developing novel safe and effective anti-HCV drugs.
Keywords: Hepatitis C virus, Natural agents, Anti-HCV activity, Botanical sources.
Graphical Abstract
Current Topics in Medicinal Chemistry
Title:HCV Inhibitors: Role of Compounds from Botanical Sources
Volume: 16 Issue: 12
Author(s): Vaishali M. Patil, Neeraj Masand and Satya Prakash Gupta
Affiliation:
Keywords: Hepatitis C virus, Natural agents, Anti-HCV activity, Botanical sources.
Abstract: The developing number of hepatitis C virus infected cases worldwide has threatened people’s health. The available therapeutic options have low specificity, side effects and high rate of drug resistance and thus potentiate the need for novel effective anti-HCV drugs. Agents obtained from natural sources offer an enormous scope of structural diversity and broad therapeutic range of coverage. This review summarizes the research and development of anti-HCV agents (plant extracts/isolated components) obtained from various natural sources along with the associated mechanism of HCV inhibition. Some of the reported examples include triterpenes, naringenin, Proanthocyanidin, curcumin, Epigallocatechin-3-gallate, quercetin and abrogates having diverse anti-HCV properties. The compiled knowledge regarding anti-HCV agents from natural sources will provide considerable information for developing novel safe and effective anti-HCV drugs.
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Cite this article as:
Patil M. Vaishali, Masand Neeraj and Gupta Prakash Satya, HCV Inhibitors: Role of Compounds from Botanical Sources, Current Topics in Medicinal Chemistry 2016; 16 (12) . https://dx.doi.org/10.2174/1568026616666151120112802
DOI https://dx.doi.org/10.2174/1568026616666151120112802 |
Print ISSN 1568-0266 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-4294 |
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