摘要
黄酮类化合物是天然植物来源的多酚化合物,具有多种生物学特性,尤其是对心血管系统,包括抗氧化、抗动脉粥样硬化、扩张血管、降压、抗血小板活性方面。这些生物学特性已经通过实验和临床研究被进行了评估。此外,广泛的综述讨论了这些多酚物质的抗动脉粥样硬化作用。然而,有限的研究已经调查了这些化合物的潜在治疗血管的作用。本文汇集了一些最近的研究,以建立不同的信号转导通路是黄酮诱导血管舒张功能的分子机制。
关键词: 心血管系统,黄酮,机制,天然产物,信号通路,血管的作用,血管舒张。
Current Medicinal Chemistry
Title:Vascular effects of flavonoids
Volume: 23 Issue: 1
Author(s): Bruno Almeida Rezende, Aline Carvalho Pereira, Steyner F. Cortes and Virginia Soares Lemos
Affiliation:
关键词: 心血管系统,黄酮,机制,天然产物,信号通路,血管的作用,血管舒张。
摘要: Flavonoids are natural plant-derived polyphenolic compounds with various biological properties particularly in the cardiovascular system, including antiatherogenic, antioxidant, vasodilation, antihypertensive, and antiplatelet activities. These biological properties have been evaluated in several experimental and clinical studies. In addition, extensive reviews have discussed the antiatherogenic effect of these polyphenols. However, limited studies have investigated the potential therapeutic vascular effects of these compounds. This review brings together some recent studies, to establish the different signaling pathways involved in the molecular mechanisms that underlie the vasodilation induced by flavonoids.
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Cite this article as:
Bruno Almeida Rezende, Aline Carvalho Pereira, Steyner F. Cortes and Virginia Soares Lemos , Vascular effects of flavonoids, Current Medicinal Chemistry 2016; 23 (1) . https://dx.doi.org/10.2174/0929867323666151111143616
DOI https://dx.doi.org/10.2174/0929867323666151111143616 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
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