A Review of Recent Patents on the ASICs as a Key Drug Target

Title:A Review of Recent Patents on the ASICs as a Key Drug Target

Volume: 9 Issue: 1

Author(s): Priscila L. Santos, Adriana G. Guimaraes, Rosana S.S. Barreto, Mairim R. Serafini, Jullyana S.S. Quintans and Lucindo J. Quintans-Junior

Affiliation:

Keywords: ASIC, antagonist, drugs, review, patent, pain, inflammation.

Abstract: Acid-sensing ion channels (ASICs) are scattered various cells of human body. Drugs like amiloride has demonstrated nonspecific antagonism ASICs. Toxins, such as Psalmotoxin-1, have been used in animal models. There are no drugs available in the market whose action mechanism acts through these channels. We revised all patents relating to pharmaceutical formulations of applicability in ASICs. Drugs acting as antagonist in ASIC1 or ASIC3 channels seem to be the most promising targets. Patent data have suggested a variety of approaches for selective ASICs drugs, such as neuroprotective and analgesic. Studies analysis suggested that ASICs are promising targets for new drugs.

Cite this article as:

L. Santos Priscila, G. Guimaraes Adriana, S.S. Barreto Rosana, R. Serafini Mairim, S.S. Quintans Jullyana and J. Quintans-Junior Lucindo, A Review of Recent Patents on the ASICs as a Key Drug Target, Recent Patents on Biotechnology 2015; 9 (1) . https://dx.doi.org/10.2174/187220830901151111124125