Abstract
Collagen, the most abundant structural protein in mammals, has drawn attention of the scientists in biomedical science to a large extent. Although collagen and collagenous materials are famous for the excellent biological properties (good bioactivity, biodegradability, biocompatibility and lower immunogenicity), they still always suffer from the limitation by the relatively weak mechanical property, chemical stability and resistance to enzymatic degradation. This paper focuses to review the various physical and chemical methods that have been reported to enhance the physicochemical property of collagen and collagenous materials in biomedical applications. The effect of modification on collagen largely depends on the reaction sites and the types of chemical bonds. Modification methods divided into physical and chemical types are discussed in detail in the present review, focusing on both the physicochemical property and the biological property.
Keywords: Collagen, modification, biocompatibility, biomedical applications.
Graphical Abstract
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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