摘要
载波技术提供了用于药物递送的智能方法,通过包埋药物载体,如纳米粒子,微球,水凝胶等,可提高药物的生物利用度,增强针对性,减少药物的毒性和副作用。本文综述了壳聚糖及其衍生物的多糖及其衍生物的化学药物和基因或蛋白质的传递。
关键词: 多糖;载体;药物传递;化学药物;基因;蛋白质。
图形摘要
Current Drug Targets
Title:The Application of Chitosan and Its Derivatives as Nanosized Carriers for the Delivery of Chemical Drugs and Genes or Proteins
Volume: 17 Issue: 7
Author(s): Qilin Tang, Gangliang Huang, Rui Ran, Yanghua Huang, Qiaoping Lou, Yuzhu Chen
Affiliation:
关键词: 多糖;载体;药物传递;化学药物;基因;蛋白质。
摘要: The carrier technology provides an intelligent approach for drug delivery by entrapping the drug into a carrier, such as nanoparticles, microspheres, hydrogels, and so on, which can increase the bioavailability of drug, enhance targeting, reduce toxicity and side effects of drug. The polysaccharides, e.g., chitosan and its derivatives, as carriers for delivery of chemical drugs and genes or proteins were summed up herein.
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Cite this article as:
Qilin Tang, Gangliang Huang, Rui Ran, Yanghua Huang, Qiaoping Lou, Yuzhu Chen , The Application of Chitosan and Its Derivatives as Nanosized Carriers for the Delivery of Chemical Drugs and Genes or Proteins, Current Drug Targets 2016; 17 (7) . https://dx.doi.org/10.2174/1389450116666151019100106
DOI https://dx.doi.org/10.2174/1389450116666151019100106 |
Print ISSN 1389-4501 |
Publisher Name Bentham Science Publisher |
Online ISSN 1873-5592 |
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