摘要
一系列的研究表明,秋水仙碱可以用于治疗心血管疾病,包括慢性冠状动脉疾病和支架植入术,近年来,秋水仙碱在心血管领域的研究已经取得了广泛的关注。不像大多数目前的临床抗炎药物,秋水仙碱独特的抗炎作用机制保证了它在心血管疾病患者中使用的安全性。而在一定的条件下如心包炎,其预防和治疗价值与急性炎症反应有关,而在冠状动脉疾病和心脏衰竭等其它情况下,其与慢性低度炎症状态相关。关于其潜在利用价值的研究依然很少。本文研究了该药在治疗急慢性冠状动脉疾病以及缺血性心脏衰竭时其治疗的主要特点、治疗的理论基础,并证明了秋水仙碱治疗这些疾病的良好前景。
关键词: 炎症、缺血、药物,药物治疗。
Current Medicinal Chemistry
Title:Colchicine in Coronary Artery Disease: An Old Acquaintance in New Attire?
Volume: 22 Issue: 36
Author(s): Georgios Giannopoulos, Christos Angelidis, Nikolaos Papoutsidakis, Vasiliki Panagopoulou, Michael W. Cleman and John Lekakis and Spyridon Deftereos
Affiliation:
关键词: 炎症、缺血、药物,药物治疗。
摘要: Colchicine has recently gained considerable attention in the field of cardiovascular research, after a number of studies showed that it may be of use in several settings of cardiovascular disease, including chronic coronary artery disease and following stent implantation. Its unique anti-inflammatory mechanism of action makes it safe to use in patients with cardiovascular disease, unlike most – if not all – currently available antiinflammatory agents. While its prophylactic and therapeutic value is well-established in certain conditions involving an acute inflammatory response, e.g. pericarditis, in other conditions, including coronary artery disease and heart failure, which are associated with a chronic low-grade inflammatory state, the evidence regarding its potential use remains sparse. In this concise review, we present key features of this drug and the rationale for colchicine therapy, in the context of acute and chronic coronary artery disease, as well as in ischemic heart failure and critically examine the evidence concerning a possible future role of colchicine treatment in these conditions.
Export Options
About this article
Cite this article as:
Georgios Giannopoulos, Christos Angelidis, Nikolaos Papoutsidakis, Vasiliki Panagopoulou, Michael W. Cleman and John Lekakis and Spyridon Deftereos , Colchicine in Coronary Artery Disease: An Old Acquaintance in New Attire?, Current Medicinal Chemistry 2015; 22 (36) . https://dx.doi.org/10.2174/0929867322666151015120458
DOI https://dx.doi.org/10.2174/0929867322666151015120458 |
Print ISSN 0929-8673 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-533X |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Carvedilol: Just Another Beta-Blocker or a Powerful Cardioprotector?
Cardiovascular & Hematological Disorders-Drug Targets Ethnopharmacological and Phytopharmaceutical Evaluation of Prosopis cineraria: An Overview and Future Prospects
Current Drug Metabolism Liver X Receptors: Potential Novel Targets in Cardiovascular Diseases
Current Drug Targets - Cardiovascular & Hematological Disorders Anti-Inflammatory Properties of Drugs from saffron crocus
Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry 1, 2-Benzisoxazole: A Privileged Structure with a Potential for Polypharmacology
Current Pharmaceutical Design Inflammation as a Therapeutic Target in Acute Ischemic Stroke Treatment
Current Topics in Medicinal Chemistry Red Wine Consumption and Prevention of Atherosclerosis: An In Vitro Model Using Human Peripheral Blood Mononuclear Cells
Current Pharmaceutical Design α-Secretase in Alzheimers Disease and Beyond: Mechanistic, Regulation and Function in the Shedding of Membrane Proteins
Current Alzheimer Research Is Elevated Norepinephrine an Etiological Factor in Some Cases of Alzheimers Disease?
Current Alzheimer Research Balaglitazone: A Second Generation Peroxisome Proliferator-Activated Receptor (PPAR) Gamma (γ) Agonist
Mini-Reviews in Medicinal Chemistry Protrhombotic Effects of Contraceptives
Current Pharmaceutical Design Extra-Hepatic Isozymes from the CYP1 and CYP2 Families as Potential Chemotherapeutic Targets
Current Topics in Medicinal Chemistry Energy Expenditure of Hunter-Gatherers: When Statistics Turns to be Unreliable
Endocrine, Metabolic & Immune Disorders - Drug Targets Editorial [Hot Topic: Pharmacogenomics: Achievements, Challenges and Prospects, for Patients, Pharmaceutical Industries and Healthcare Systems (Guest Editor: Despina Sanoudou)]
Current Pharmaceutical Design Current Strategies and Future Perspective for the Effective Treatment of Diabetic Retinopathy
Current Drug Therapy Metabolomics
Current Drug Metabolism Long-Term Effectiveness and Safety Outcomes in HIV-1-Infected Patients After a Median Time of 6 Years on Nevirapine
Current HIV Research Prevalence of Cardiovascular and Metabolic Events in Patients Prescribed Clozapine: A Retrospective Observational, Clinical Cohort Study
Current Drug Safety Cannabinoids and Schizophrenia: Therapeutic Prospects
Current Pharmaceutical Design Cellular Mechanisms of the Protective Effect of Polyphenols on the Neurovascular Unit in Strokes
Cardiovascular & Hematological Agents in Medicinal Chemistry